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Zinc intake, neoplastic DNA synthesis, and chemical carcinogenesis in rats and mice

DNA synthesis in a transplanted hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was significantly reduced (P less than 0.01) in rats maintained on diets low (0.4 mug/g) or high (greater than or equal to 500 mug/g) in zinc when compared with control animals given 60 mug zinc/g. 3-Methylc...

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Published in:	JNCI : Journal of the National Cancer Institute 1975-07, Vol.55 (1), p.195
Main Authors:	Duncan, J R, Dreosti, I E
Format:	Article
Language:	English
Subjects:	Animals Carcinoma, Hepatocellular - metabolism Depression, Chemical DNA, Neoplasm - biosynthesis Dose-Response Relationship, Drug Female Liver Neoplasms - metabolism Methylcholanthrene - antagonists & inhibitors Mice Neoplasms, Experimental Rats Thymidine - metabolism Zinc - metabolism Zinc - pharmacology
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container_title	JNCI : Journal of the National Cancer Institute
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creator	Duncan, J R Dreosti, I E
description	DNA synthesis in a transplanted hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was significantly reduced (P less than 0.01) in rats maintained on diets low (0.4 mug/g) or high (greater than or equal to 500 mug/g) in zinc when compared with control animals given 60 mug zinc/g. 3-Methylcholanthrene-induced carcinogenesis was considerably lowered in mice receiving the same low or high zinc diets during the induction periods.
doi_str_mv	10.1093/jnci/55.1.195
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source	Oxford University Press Archive
subjects	Animals Carcinoma, Hepatocellular - metabolism Depression, Chemical DNA, Neoplasm - biosynthesis Dose-Response Relationship, Drug Female Liver Neoplasms - metabolism Methylcholanthrene - antagonists & inhibitors Mice Neoplasms, Experimental Rats Thymidine - metabolism Zinc - metabolism Zinc - pharmacology
title	Zinc intake, neoplastic DNA synthesis, and chemical carcinogenesis in rats and mice
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