A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia

Department of Biomedical Science and Biotechnology, University of Cagliari, Ospedale Microcitemico, Italy. renzo.galanello@mcweb.unica.it We compared the safety and efficacy of alternating deferoxamine and deferiprone with that of deferoxamine monotherapy. Sixty transfusion-dependent thalassemia pat...

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Bibliographic Details
Published in:Haematologica (Roma) 2006-09, Vol.91 (9), p.1241-1243
Main Authors: Galanello, R, Kattamis, A, Piga, A, Fischer, R, Leoni, G, Ladis, V, Voi, V, Lund, U, Tricta, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemias. Hemoglobinopathies
Biological and medical sciences
Deferoxamine - administration & dosage
Deferoxamine - adverse effects
Diseases of red blood cells
Drug Therapy, Combination
Female
Hematologic and hematopoietic diseases
Humans
Iron Overload - drug therapy
Male
Medical sciences
Pyridones - administration & dosage
Pyridones - adverse effects
Thalassemia - complications
Thalassemia - drug therapy
Treatment Outcome
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Summary:Department of Biomedical Science and Biotechnology, University of Cagliari, Ospedale Microcitemico, Italy. renzo.galanello@mcweb.unica.it We compared the safety and efficacy of alternating deferoxamine and deferiprone with that of deferoxamine monotherapy. Sixty transfusion-dependent thalassemia patients regularly treated with deferoxamine were randomized to continue deferoxamine alone or to receive an alternating therapy for one year. Both arms resulted in equivalent decreases of serum ferritin and liver iron concentration. There was no significant difference in the proportion of patients with adverse events in the two therapy groups although the nature of the adverse events differed according to the chelation regimen.
ISSN:0390-6078
1592-8721