Performance of dedicated emission mammotomography for various breast shapes and sizes

• Published in: Physics in medicine & biology 2006-10, Vol.51 (19), p.5051-5064
• Main Authors: Brzymialkiewicz, C N, Tornai, M P, McKinley, R L, Cutler, S J, Bowsher, J E
• Format: Article
• Language: English
• Subjects: Breast - pathology; Equipment Design; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Mammography - methods; Phantoms, Imaging; Tomography, Emission-Computed - methods
• ISSN: 0031-9155; 1361-6560
• DOI: 10.1088/0031-9155/51/19/021

We evaluate the effect of breast shape and size and lesion location on a dedicated emission mammotomography system developed in our lab. The hemispherical positioning gantry allows ample flexibility in sampling a pendant, uncompressed breast. Realistic anthropomorphic torso (which includes the upper portion of the arm) and breast phantoms draw attention to the necessity of using unique camera trajectories (orbits) rather than simple circular camera trajectories. We have implemented several novel three-dimensional (3D) orbits with fully contoured radius-of-rotation capability for compensating for the positioning demands that emerge from different breast shapes and sizes. While a general orbit design may remain the same between two different breasts, the absolute polar tilt range and radius-of-rotation range may vary. We have demonstrated that using 3D orbits with increased polar camera tilt, lesions near the chest wall can be visualized for both large and small sized breasts (325 ml to 1,060 ml), for a range of intrinsic contrasts (three to ten times higher activity concentration in the lesion than breast background). Overall, nearly complete 3D acquisition schemes yield image data with relatively high lesion SNRs and contrasts and with minimal distortion of the uncompressed breast shape.