Trends in detection of warfare agents Detection methods for ricin, staphylococcal enterotoxin B and T-2 toxin

An overview of the different detection methods available for ricin, staphylococcal enterotoxin B (SEB) and T-2 toxin is presented here. These toxins are potential biological warfare agents (BWA). The aim of this review is not to cover all the papers that had been published but rather to give an over...

Full description

Saved in:
Bibliographic Details
Published in:Journal of chromatography 2006-11, Vol.1133 (1-2), p.1-12
Main Authors: SIOK GHEE LER, FOOK KAY LEE, GOPALAKRISHNAKONE, P
Format: Article
Language:English
Subjects:
Bacterial Toxins - analysis
Bacterial Toxins - chemistry
Biological and medical sciences
Biological Warfare - trends
Chemical Warfare Agents - analysis
Chemical Warfare Agents - chemistry
Enterotoxins - analysis
Enterotoxins - chemistry
General aspects. Methods
Immunoassay - methods
Mass Spectrometry - methods
Medical sciences
Molecular Structure
Ricin - analysis
Ricin - chemistry
Toxicology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An overview of the different detection methods available for ricin, staphylococcal enterotoxin B (SEB) and T-2 toxin is presented here. These toxins are potential biological warfare agents (BWA). The aim of this review is not to cover all the papers that had been published but rather to give an overall picture of the trend in the detection methodologies for potential biological warfare agents as we do see the emerging threats from these three toxins. The advantages and disadvantages of each methodology as well as the detection limit will be reviewed. It seems that mass spectrometry has created a niche for analysis of proteinaceous toxins, ricin and SEB as well as molecular toxin, T-2 toxin given its high sensitivity, high selectivity, high specificity and capability to identify and quantify unknown agents simultaneously in a short time frame. But its main drawbacks are its sophisticated instrumentation and its high cost. Improvised immunoassay may be an alternative.
ISSN:0021-9673
DOI:10.1016/j.chroma.2006.08.078