Effect of the concomitant administration of indomethacin or ibuprofen on amikacin pharmacokinetics in premature newborns

To evaluate whether the concomitant administration of ibuprofen or indomethacin plus amikacin may alter the latter drug s pharmacokinetic parameters, and hence amikacin plasma levels. Retrospective cohort study performed by reviewing the medical records of premature children with persistent ductus a...

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Bibliographic Details
Published in:Farmacia hospitalaria 2006-05, Vol.30 (3), p.149
Main Authors: Cuesta Grueso, C, Gimeno Navarro, A, Marqués Miñana, M R, Peris Ribera, J E, Morcillo Sopena, F, Poveda Andrés, J L
Format: Article
Language:Spanish
Subjects:
Amikacin - pharmacokinetics
Anti-Bacterial Agents - pharmacokinetics
Cohort Studies
Cyclooxygenase Inhibitors - administration & dosage
Cyclooxygenase Inhibitors - pharmacology
Drug Interactions
Drug Therapy, Combination
Female
Humans
Ibuprofen - administration & dosage
Ibuprofen - pharmacology
Indomethacin - administration & dosage
Indomethacin - pharmacology
Infant, Newborn
Infant, Premature
Male
Retrospective Studies
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Summary:To evaluate whether the concomitant administration of ibuprofen or indomethacin plus amikacin may alter the latter drug s pharmacokinetic parameters, and hence amikacin plasma levels. Retrospective cohort study performed by reviewing the medical records of premature children with persistent ductus arteriosus receiving amikacin and ibuprofen, or amikacin and indomethacin. They were divided up into three groups: group 1: treatment with amikacin went before indomethacin or ibuprofen; group 2: simultaneously treated with amikacin and indomethacin; group 3: simultaneously treated with amikacin and ibuprofen. Pharmacokinetic parameters, distribution volume, and amikacin clearance were measured using the PKS program (a non-linear regression method). Half life was determined from previous parameters. Twenty-eight patients were included. No statistically significant differences were found among pharmacokinetic parameters corresponding to each study group. Further studies are needed with a greater number of patients and currently recommended doses to assess the influence of indomethacin and ibuprofen in the pharmacokinetics of amikacin in premature children with persistent ductus arteriosus.
ISSN:1130-6343