Cutaneous necrosis due to interferon alpha in a patient with melanoma

We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condi...

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Bibliographic Details
Published in:Actas dermo-sifiliográficas 2006-10, Vol.97 (8), p.539
Main Authors: Aguilar García, Guadalupe, Serrano Falcón, Cristina, Serrano Falcón, Maria del Mar, Carmona, Maria Dolores, Linares Solano, Juan, Serrano Ortega, Salvio
Format: Article
Language:Spanish
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Arm
Chemotherapy, Adjuvant
Debridement
Follow-Up Studies
Humans
Injections, Intravenous
Interferon-alpha - administration & dosage
Interferon-alpha - adverse effects
Male
Melanoma - drug therapy
Melanoma - pathology
Melanoma - surgery
Middle Aged
Necrosis - chemically induced
Necrosis - pathology
Ointments
Recombinant Proteins
Skin - pathology
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Skin Ulcer - chemically induced
Skin Ulcer - drug therapy
Skin Ulcer - surgery
Time Factors
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Description
Summary:We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN.
ISSN:0001-7310
DOI:10.1016/S0001-7310(06)73460-3