Treatment of squamous cell carcinoma of the pancreas with gemcitabine

• Published in: Gastroentérologie clinique et biologique 2006-10, Vol.30 (10), p.1217
• Main Authors: Bideau, Karine, Metges, Jean-Philippe, Bayle, Sophie, André, Michel, Robaszkiewicz, Michel, Lagarde, Nicole, Labat, Jean-Paul
• Format: Article
• Language: fre
• Subjects: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic - administration & dosage; Antimetabolites, Antineoplastic - therapeutic use; Biopsy; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - surgery; Combined Modality Therapy; Deoxycytidine - administration & dosage; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Humans; Liver - pathology; Liver Neoplasms - drug therapy; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - secondary; Male; Middle Aged; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - radiotherapy; Pancreatic Neoplasms - surgery; Prognosis; Time Factors; Treatment Outcome
• ISSN: 0399-8320
• DOI: 10.1016/S0399-8320(06)73515-1

Primary squamous cell carcinoma of the pancreas is a rare tumor. We report a case of a 49 years old patient with a metastatic squamous cell carcinoma of the pancreas. Histological diagnosis was established by echoguided biopsy of the liver. Due to that, we cannot be sure that this tumor was not adenosquamous with a metastatic component from only the squamous part of the lesion. Two types of chemotherapy have been performed. The first one was radiochemotherapy with an association of 5FU and cisplatinum. Gemcitabin was the second one. An objective response was obtained with gemcitabin and the patient's health improved. To our knowledge, this has never had been reported beforehand. However the prognosis of this cancer remains poor. Overall survival was 8 months.