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The Human Striatum is Necessary for Responding to Changes in Stimulus Relevance
Various lines of evidence suggest that the striatum is implicated in cognitive flexibility. The neuropsychological evidence has, for the most part, been based on research with patients with Parkinson's disease, which is accompanied by chemical disruption of both the striatum and the prefrontal...
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| Published in: | Journal of cognitive neuroscience 2006-12, Vol.18 (12), p.1973-1983 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c612t-ad00d65770f90e294b03eef74bc05fa1c1997177b865c8748d9e783817bcbf203 |
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| cites | cdi_FETCH-LOGICAL-c612t-ad00d65770f90e294b03eef74bc05fa1c1997177b865c8748d9e783817bcbf203 |
| container_end_page | 1983 |
| container_issue | 12 |
| container_start_page | 1973 |
| container_title | Journal of cognitive neuroscience |
| container_volume | 18 |
| creator | Cools, R. Ivry, R. B. D'Esposito, M. |
| description | Various lines of evidence suggest that the striatum is implicated in cognitive flexibility. The neuropsychological evidence has, for the most part, been based on research with patients with Parkinson's disease, which is accompanied by chemical disruption of both the striatum and the prefrontal cortex. The present study examined this issue by testing patients with focal lesions of the striatum on a task measuring two forms of cognitive switching. Patients with striatal, but not frontal lobe lesions, were impaired in switching between concrete sensory stimuli. By contrast, both patient groups were unimpaired when switching between abstract task rules relative to baseline nonswitch trials. These results reveal a dissociation between two distinct forms of cognitive f lexibility, providing converging evidence for a role of the striatum in f lexible control functions associated with the selection of behaviorally relevant stimuli. |
| doi_str_mv | 10.1162/jocn.2006.18.12.1973 |
| format | article |
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B.</creatorcontrib><creatorcontrib>D'Esposito, M.</creatorcontrib><title>The Human Striatum is Necessary for Responding to Changes in Stimulus Relevance</title><title>Journal of cognitive neuroscience</title><addtitle>J Cogn Neurosci</addtitle><description>Various lines of evidence suggest that the striatum is implicated in cognitive flexibility. The neuropsychological evidence has, for the most part, been based on research with patients with Parkinson's disease, which is accompanied by chemical disruption of both the striatum and the prefrontal cortex. The present study examined this issue by testing patients with focal lesions of the striatum on a task measuring two forms of cognitive switching. Patients with striatal, but not frontal lobe lesions, were impaired in switching between concrete sensory stimuli. By contrast, both patient groups were unimpaired when switching between abstract task rules relative to baseline nonswitch trials. These results reveal a dissociation between two distinct forms of cognitive f lexibility, providing converging evidence for a role of the striatum in f lexible control functions associated with the selection of behaviorally relevant stimuli.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anatomical correlates of behavior</subject><subject>Behavior</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Damage, Chronic - physiopathology</subject><subject>Brain Damage, Chronic - psychology</subject><subject>Brain research</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Female</subject><subject>Frontal Lobe - physiopathology</subject><subject>Functional Laterality - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Measurement techniques</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neostriatum - physiopathology</subject><subject>Nervous system</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Reaction Time - physiology</subject><subject>Stroke - physiopathology</subject><subject>Stroke - psychology</subject><subject>Testing</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><subject>Visual Fields - physiology</subject><subject>Visual Perception - physiology</subject><issn>0898-929X</issn><issn>1530-8898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqF0V1rFDEUBuAgil2r_0BkEPRuxnPyMUkuZbG2UCxoBe9CJpNps8zHmswU9Nc3wy5UpNCr3DznTXJeQt4iVIg1_bSb3FhRgLpCVSGtUEv2jGxQMCiV0uo52UA-Sk31rxPyKqUdAFBR85fkBCVSjUpsyNX1rS_Ol8GOxY85BjsvQxFS8c07n5KNf4puisV3n_bT2IbxppinYntrxxufirCOhGHpl5RF7-_s6Pxr8qKzffJvjucp-Xn25Xp7Xl5efb3Yfr4sXY10Lm0L0NZCSug0eKp5A8z7TvLGgegsOtRaopSNqoVTkqtWe6mYQtm4pqPATsnHQ-4-Tr8Xn2YzhOR839vRT0sytULNteJPQtQCBecyw_f_wd20xDF_wlDKQArGaEb8gFycUoq-M_sYhrwng2DWWsxai1lrMagMUrPWksfeHbOXZvDtw9Cxhww-HIFNzvZdzLsM6cEpxoGpNQgObgj_vO-Juy8eGVnpHaqQFQNKs6dAMccYUOZv2D-edQ_p3rrD</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Cools, R.</creator><creator>Ivry, R. 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B. ; D'Esposito, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c612t-ad00d65770f90e294b03eef74bc05fa1c1997177b865c8748d9e783817bcbf203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anatomical correlates of behavior</topic><topic>Behavior</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Damage, Chronic - physiopathology</topic><topic>Brain Damage, Chronic - psychology</topic><topic>Brain research</topic><topic>Cognition & reasoning</topic><topic>Cognition - physiology</topic><topic>Female</topic><topic>Frontal Lobe - physiopathology</topic><topic>Functional Laterality - physiology</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Journal of cognitive neuroscience, 2006-12, Vol.18 (12), p.1973-1983 |
| issn | 0898-929X 1530-8898 |
| language | eng |
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| source | MIT Press Journals |
| subjects | Adult Adult and adolescent clinical studies Aged Aged, 80 and over Anatomical correlates of behavior Behavior Behavioral psychophysiology Biological and medical sciences Brain Brain Damage, Chronic - physiopathology Brain Damage, Chronic - psychology Brain research Cognition & reasoning Cognition - physiology Female Frontal Lobe - physiopathology Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Humans Magnetic Resonance Imaging Male Measurement techniques Medical sciences Middle Aged Neostriatum - physiopathology Nervous system Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - physiology Psychopathology. Psychiatry Reaction Time - physiology Stroke - physiopathology Stroke - psychology Testing Tomography, X-Ray Computed Tumors Visual Fields - physiology Visual Perception - physiology |
| title | The Human Striatum is Necessary for Responding to Changes in Stimulus Relevance |
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