Foreign body reaction to materials implanted as biocompatible for internal fixation

After implantation of resorbable materials for internal fixation, foreign body reactions are described in 0-47% of cases. Copolymers of poly-l-lactic acid (PLLA) and polyglycolic acid (PGA) seem to offer better biocompatibility than other materials. One of our patients had a midfacial fracture, whic...

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Bibliographic Details
Published in:HNO 2008-05, Vol.56 (5), p.545
Main Authors: Thiele, Alexander, Bilkenroth, U, Bloching, M, Knipping, St
Format: Article
Language:eng ; ger
Subjects:
Adult
Biocompatible Materials - adverse effects
Foreign-Body Reaction - diagnosis
Foreign-Body Reaction - etiology
Foreign-Body Reaction - prevention & control
Fracture Fixation, Internal - adverse effects
Fracture Fixation, Internal - instrumentation
Humans
Male
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Description
Summary:After implantation of resorbable materials for internal fixation, foreign body reactions are described in 0-47% of cases. Copolymers of poly-l-lactic acid (PLLA) and polyglycolic acid (PGA) seem to offer better biocompatibility than other materials. One of our patients had a midfacial fracture, which we fixed using a resorbable system based on PLLA-PGA (82%-18%); a foreign body reaction developed after 22 months. When resorbable materials are used it is essential to be aware specifically of the risk of foreign body reactions, especially when the facial area is involved. This risk must be discussed with the patient in some detail during the preoperative period.
ISSN:1433-0458
DOI:10.1007/s00106-006-1530-4