Telomerase: Going Beyond the Ends

To date, the major function attributed to telomerase has been the elongation of telomeres. Recent studies have assigned new biochemical properties to telomerase by implicating a role in tumor metastasis and cellular differentiation by virtue of its modulation of novel cell signaling pathways such as...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2007-03, Vol.6 (5), p.546-549
Main Authors: De Semir, David, Nosrati, Mehdi, Li, Shang, Kashani-Sabet, Mohammed
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Differentiation - genetics
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cellular Senescence - genetics
Cycle
DNA Damage - genetics
Humans
Landes
Organogenesis
Proteins
Telomerase - genetics
Telomerase - metabolism
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Summary:To date, the major function attributed to telomerase has been the elongation of telomeres. Recent studies have assigned new biochemical properties to telomerase by implicating a role in tumor metastasis and cellular differentiation by virtue of its modulation of novel cell signaling pathways such as glycolysis. In this Perspective we will discuss these recent results that have provided additional insight into the involvement of telomerase in cellular processes other than telomere maintenance at chromosome ends.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.6.5.3980