Importance of [18F]fluorodeoxyglucose-positron emission tomography scanning for the monitoring of responses to immunotherapy in follicular lymphoma

We prospectively investigated the use of [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) to kinetically monitor cell activation in six follicular lymphoma patients vaccinated with tumor lysate-pulsed autologous dendritic cells. PET revealed additional initial nodes suggestive of lym...

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Bibliographic Details
Published in:Leukemia & lymphoma 2007-02, Vol.48 (2), p.381-388
Main Authors: Baudard, Marion, Comte, Frederic, Conge, Anne Marie, Mariano-Goulart, Denis, Klein, Bernard, Rossi, Jean François
Format: Article
Language:English
Subjects:
Adult
anti-tumor vaccine
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer Vaccines - therapeutic use
Combined Modality Therapy
Dendritic Cells - immunology
Diagnosis, Differential
FDG-PET
Female
Fluorodeoxyglucose F18 - pharmacokinetics
follicular lymphoma
Humans
Immunotherapy
Lymphoma, Follicular - diagnostic imaging
Lymphoma, Follicular - immunology
Lymphoma, Follicular - therapy
Male
Middle Aged
Neoplasm, Residual - diagnosis
Neoplasm, Residual - drug therapy
Prognosis
Prospective Studies
Radionuclide Imaging
Radiopharmaceuticals - pharmacokinetics
Sensitivity and Specificity
Survival Rate
Tissue Distribution
Tomography, X-Ray Computed
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Summary:We prospectively investigated the use of [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) to kinetically monitor cell activation in six follicular lymphoma patients vaccinated with tumor lysate-pulsed autologous dendritic cells. PET revealed additional initial nodes suggestive of lymphoma, that were of less than 10 mm of diameter on computed tomography, and documented disease progression with sensitivity, even within loci with no significant variations of CT findings. Although tracer fixation was not observed in the inguinal nodes draining the dendritic cell intradermal injection sites in the six patients, a transient marked increase in FDG uptake within malignant nodes was observed early after vaccine administration in a patient who achieved complete remission. In non-responding patients, we observed a continuous increase of FDG uptake associated with an increase in the size and number of pathological nodes locus, or of involved loci. FDG-PET is a non-invasive imaging procedure that might be of crucial interest to detect cell responses induced by immunotherapies.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190601094354