Cl- conduction of GABA(A) receptor complex on synaptic membranes in rat cortex at the early stage of chronic cerebral epileptization

Experiments on Wistar rats showed that muscimol-stimulated Cl(-) conduction of synaptoneurosomes, isolated from the cerebral cortex increased after 5-day systemic treatment with subconvulsive doses of pentylene tetrasole during the initial stage of pharmacological pentylene tetrasole kindling, chara...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-08, Vol.142 (2), p.176
Main Authors: Rebrov, I G, Karpova, M N, Andreev, A A, Klishina, N Yu, Kalinina, M V, Kuzina, O S, Kuznetsova, L V
Format: Article
Language:eng ; rus
Subjects:
Animals
Cerebral Cortex - metabolism
Chlorides - metabolism
Convulsants - toxicity
Epilepsy - chemically induced
Epilepsy - metabolism
Male
Pentylenetetrazole - toxicity
Rats
Rats, Wistar
Receptors, GABA-A - metabolism
Synaptic Membranes - metabolism
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Summary:Experiments on Wistar rats showed that muscimol-stimulated Cl(-) conduction of synaptoneurosomes, isolated from the cerebral cortex increased after 5-day systemic treatment with subconvulsive doses of pentylene tetrasole during the initial stage of pharmacological pentylene tetrasole kindling, characterized by gradually augmenting convulsive readiness of the brain. This indicates an increase in functional activity of the GABA(A) receptor/Cl(-) ionophore complex.
ISSN:0007-4888
DOI:10.1007/s10517-006-0320-z