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Hyperbaric oxygen in traumatic brain injury

Objectives: This critical literature review examines historical and current investigations on the efficacy and mechanisms of hyperbaric oxygen (HBO) treatment in traumatic brain injury (TBI). Potential safety risks and oxygen toxicity, as well as HBO's future potential, are also discussed. Meth...

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Published in:Neurological research (New York) 2007-03, Vol.29 (2), p.162-172
Main Authors: Rockswold, Sarah B., Rockswold, Gaylan L., Defillo, Archie
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container_title Neurological research (New York)
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creator Rockswold, Sarah B.
Rockswold, Gaylan L.
Defillo, Archie
description Objectives: This critical literature review examines historical and current investigations on the efficacy and mechanisms of hyperbaric oxygen (HBO) treatment in traumatic brain injury (TBI). Potential safety risks and oxygen toxicity, as well as HBO's future potential, are also discussed. Methods: Directed literature review. Results: Historically, cerebral vasoconstriction and increased oxygen availability were seen as the primary mechanisms of HBO in TBI. HBO now appears to be improving cerebral aerobic metabolism at a cellular level, namely, by enhancing damaged mitochondrial recovery. HBO given at the ideal treatment paradigm, 1.5 ATA for 60 minutes, does not appear to produce oxygen toxicity and is relatively safe. Discussion: The use of HBO in TBI remains controversial. Growing evidence, however, shows that HBO may be a potential treatment for patients with severe brain injury. Further investigations, including a multicenter prospective randomized clinical trial, will be required to definitively define the role of HBO in severe TBI.
doi_str_mv 10.1179/016164107X181798
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subjects Animals
Brain - blood supply
Brain - metabolism
Brain - physiopathology
Brain Injuries - physiopathology
Brain Injuries - therapy
CEREBRAL METABOLISM
Cerebrovascular Circulation - physiology
Clinical Trials as Topic - statistics & numerical data
Disease Models, Animal
Humans
HYPERBARIC OXYGEN
Hyperbaric Oxygenation - adverse effects
Hyperbaric Oxygenation - standards
Hyperbaric Oxygenation - trends
Hypoxia-Ischemia, Brain - etiology
Hypoxia-Ischemia, Brain - physiopathology
Hypoxia-Ischemia, Brain - therapy
INTRACRANIAL PRESSURE
Oxygen Consumption - physiology
TRAUMATIC BRAIN INJURY
Treatment Outcome
title Hyperbaric oxygen in traumatic brain injury
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