Effects of ketamine and thiopentone anesthesia on serum lipid parameters in adult bonnet monkeys (Macaca radiata)

• Published in: Journal of the American Association for Laboratory Animal Science 2007-05, Vol.46 (3), p.21-23
• Main Authors: Perumal, N, Ramasamy, V, Kumar, M.J.M, Majumdar, S.S
• Format: Article
• Language: English
• Subjects: adult animals; anesthesia; anesthetics; Anesthetics, Intravenous - pharmacology; Animals; blood lipids; cholesterol; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, VLDL - blood; drug evaluation; Female; high density lipoprotein; ketamine; Ketamine - pharmacology; Lipid Metabolism - drug effects; Lipids - blood; Macaca radiata; Macaca radiata - blood; monkeys; Thiopental - pharmacology; triacylglycerols; Triglycerides - blood; very low density lipoprotein
• ISSN: 1559-6109; 2769-6677

We investigated the effect of anesthesia on serum lipid parameters in adult bonnet macaques (Macaca radiata). We treated 10 animals with ketamine hydrochloride (15 mg/kg intramuscularly) and, on the next day, thiopentone sodium (25 mg/kg intravenously). Blood samples were obtained before and after anesthetic treatment. Serum cholesterol, triglycerides, very low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) were measured by autoanalyzer. Ketamine anesthesia significantly decreased serum cholesterol and HDL levels, whereas thiopentone significantly reduced triglycerides and VLDL and increased HDL values. Although the effects of ketamine hydrochloride and thiopentone sodium on serum biochemical values have been reported, no literature addressing the effect of anesthesia on lipid parameters in bonnet macaques is available. These findings will be useful in designing experiments assessing pathologic and toxicologic changes in serum lipid parameters and interpreting data obtained from adult bonnet monkeys.