Single Versus Repeated Sessions of Ketamine-Assisted Psychotherapy for People with Heroin Dependence

A prior study found that one ketamine-assisted psychotherapy session was significantly more effective than active placebo in promoting abstinence (Krupitsky et al. 2002). In this study of the efficacy of single versus repeated sessions of ketamine-assisted psychotherapy in promoting abstinence in pe...

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Bibliographic Details
Published in:Journal of psychoactive drugs 2007-03, Vol.39 (1), p.13-19
Main Authors: Krupitsky, Evgeny M., Burakov, Andrei M., Dunaevsky, Igor V., Romanova, Tatyana N., Slavina, Tatyana Y., Grinenko, Alexander Y.
Format: Article
Language:English
Subjects:
Adult
Drug addiction
Drug Administration Schedule
Female
Follow-Up Studies
hallucinogens
Hallucinogens - administration & dosage
Hallucinogens - adverse effects
Heroin
heroin addiction
Heroin Dependence - drug therapy
Heroin Dependence - mortality
Heroin Dependence - psychology
Heroin Dependence - therapy
Hospitals
Humans
Kaplan-Meier Estimate
ketamine
Ketamine - administration & dosage
Ketamine - adverse effects
Male
Placebo effect
psychedelics
Psychology
Psychotherapy
Psychotherapy - methods
Psychotropic drugs
Russia - epidemiology
Studies
Substance abuse treatment
Time Factors
treatment
Treatment Outcome
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Summary:A prior study found that one ketamine-assisted psychotherapy session was significantly more effective than active placebo in promoting abstinence (Krupitsky et al. 2002). In this study of the efficacy of single versus repeated sessions of ketamine-assisted psychotherapy in promoting abstinence in people with heroin dependence, 59 detoxified inpatients with heroin dependence received a ketamineassisted psychotherapy (KPT) session prior to their discharge from an addiction treatment hospital, and were then randomized into two treatment groups. Participants in the first group received two addiction counseling sessions followed by two KPT sessions, with sessions scheduled on a monthly interval (multiple KPT group). Participants in the second group received two addiction counseling sessions on a monthly interval, but no additional ketamine therapy sessions (single KPT group). At one-year follow-up, survival analysis demonstrated a significantly higher rate of abstinence in the multiple KPT group. Thirteen out of 26 subjects (50%) in the multiple KPT group remained abstinent. compared to 6 out of 27 subjects (22.2%) in the single KPT group (p < 0.05). No differences between groups were found in depression, anxiety, craving for heroin, or their understanding of the meaning of their lives. It was concluded that three sessions of ketamine-assisted psychotherapy are more effective than a single session for the treatment of heroin addiction.
ISSN:0279-1072
2159-9777
DOI:10.1080/02791072.2007.10399860