Host Genetic Resistance to Symptomatic Norovirus (GGII.4) Infections in Denmark

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2007-08, Vol.45 (8), p.2720-2722
Main Authors: Kindberg, Elin, Åkerlind, Britt, Johnsen, Christina, Knudsen, Jenny Dahl, Heltberg, Ole, Larson, Göran, Böttiger, Blenda, Svensson, Lennart
Format: Article
Language:English
Subjects:
Biological and medical sciences
Caliciviridae Infections - epidemiology
Caliciviridae Infections - genetics
Caliciviridae Infections - virology
Codon, Nonsense
Denmark
Disease Outbreaks
Fucosyltransferases - genetics
Fundamental and applied biological sciences. Psychology
Galactoside 2-alpha-L-fucosyltransferase
Genotype
Humans
Immunity, Innate - genetics
MEDICIN
MEDICINE
Microbiology
Norovirus
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Virology
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Summary:A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.
ISSN:0095-1137
1098-660X
1098-660X
1098-5530
DOI:10.1128/JCM.00162-07