Beclin 1 mRNA Strongly Correlates with Bcl-XLmRNA Expression in Human Hepatocellular Carcinoma

Beclin 1 physically associates with Bcl-xL and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was...

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Bibliographic Details
Published in:Cancer investigation 2007-06, Vol.25 (4), p.226-231
Main Authors: Daniel, F., Legrand, A., Pessayre, D., Borrega-Pires, F., Mbida, L., Lardeux, B., Degott, C., van Nhieu, J. Tran, Bernuau, D.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Apoptosis
Apoptosis Regulatory Proteins - genetics
Autophagy
Bcl-X
bcl-X Protein - genetics
Beclin 1
Carcinoma, Hepatocellular - metabolism
Female
Hepatocellular carcinoma
Humans
Liver Neoplasms - metabolism
Male
Membrane Proteins - genetics
Middle Aged
Proliferating Cell Nuclear Antigen - genetics
Proto-Oncogene Proteins c-bcl-2 - genetics
RNA, Messenger - analysis
Tumor suppressor
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Summary:Beclin 1 physically associates with Bcl-xL and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-XL mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-XL expression in HCC may suggest cooperation in the regulation of apoptosis.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357900701206323