Loading…
Beclin 1 mRNA Strongly Correlates with Bcl-XLmRNA Expression in Human Hepatocellular Carcinoma
Beclin 1 physically associates with Bcl-xL and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was...
Saved in:
| Published in: | Cancer investigation 2007-06, Vol.25 (4), p.226-231 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 231 |
| container_issue | 4 |
| container_start_page | 226 |
| container_title | Cancer investigation |
| container_volume | 25 |
| creator | Daniel, F. Legrand, A. Pessayre, D. Borrega-Pires, F. Mbida, L. Lardeux, B. Degott, C. van Nhieu, J. Tran Bernuau, D. |
| description | Beclin 1 physically associates with Bcl-xL and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-XL mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-XL expression in HCC may suggest cooperation in the regulation of apoptosis. |
| doi_str_mv | 10.1080/07357900701206323 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_17612932</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70693957</sourcerecordid><originalsourceid>FETCH-LOGICAL-i260t-335c541227b6927207c308c3aa0c5a3d3da093a3d113c07c4eb62c7c731bdd623</originalsourceid><addsrcrecordid>eNqFkU1rGzEQhkVJaZy0P6CXsKfcNhlpvJKX5BKbfIFpoR_QU8VYK8cK2pUj7ZL630fOx6GEkMvMwDzvMLwvY185HHGYwDEorFQNoIALkCjwAxvxCkU55rXYYaPtvsyA2mV7Kd0C8IlQ1Se2y5XkokYxYn-n1njXFbxof3w7K372MXQ3flPMQozWU29Tce_6VTE1vvwzf2TO_62jTcmFrsjCq6GlXO2a-mCs94OnWMwoGteFlj6zj0vyyX557vvs98X5r9lVOf9-eT07m5dOSOhLxMpUYy6EWshaKAHKIEwMEoGpCBtsCGrMA-do8nJsF1IYZRTyRdNIgfvs8OnuOoa7waZety5t36HOhiFpBbLGulLvgrxWIISUGTx4BodFaxu9jq6luNEv1mXg9Alw3TLElu5D9I3uaeNDXEbqjEsaOehtUvpVUll-8p98Zcn3K0PR6tswxC67pd9WPwCdBZR7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19702266</pqid></control><display><type>article</type><title>Beclin 1 mRNA Strongly Correlates with Bcl-XLmRNA Expression in Human Hepatocellular Carcinoma</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Daniel, F. ; Legrand, A. ; Pessayre, D. ; Borrega-Pires, F. ; Mbida, L. ; Lardeux, B. ; Degott, C. ; van Nhieu, J. Tran ; Bernuau, D.</creator><creatorcontrib>Daniel, F. ; Legrand, A. ; Pessayre, D. ; Borrega-Pires, F. ; Mbida, L. ; Lardeux, B. ; Degott, C. ; van Nhieu, J. Tran ; Bernuau, D.</creatorcontrib><description>Beclin 1 physically associates with Bcl-xL and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-XL mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-XL expression in HCC may suggest cooperation in the regulation of apoptosis.</description><identifier>ISSN: 0735-7907</identifier><identifier>EISSN: 1532-4192</identifier><identifier>DOI: 10.1080/07357900701206323</identifier><identifier>PMID: 17612932</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Apoptosis Regulatory Proteins - genetics ; Autophagy ; Bcl-X ; bcl-X Protein - genetics ; Beclin 1 ; Carcinoma, Hepatocellular - metabolism ; Female ; Hepatocellular carcinoma ; Humans ; Liver Neoplasms - metabolism ; Male ; Membrane Proteins - genetics ; Middle Aged ; Proliferating Cell Nuclear Antigen - genetics ; Proto-Oncogene Proteins c-bcl-2 - genetics ; RNA, Messenger - analysis ; Tumor suppressor</subject><ispartof>Cancer investigation, 2007-06, Vol.25 (4), p.226-231</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17612932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daniel, F.</creatorcontrib><creatorcontrib>Legrand, A.</creatorcontrib><creatorcontrib>Pessayre, D.</creatorcontrib><creatorcontrib>Borrega-Pires, F.</creatorcontrib><creatorcontrib>Mbida, L.</creatorcontrib><creatorcontrib>Lardeux, B.</creatorcontrib><creatorcontrib>Degott, C.</creatorcontrib><creatorcontrib>van Nhieu, J. Tran</creatorcontrib><creatorcontrib>Bernuau, D.</creatorcontrib><title>Beclin 1 mRNA Strongly Correlates with Bcl-XLmRNA Expression in Human Hepatocellular Carcinoma</title><title>Cancer investigation</title><addtitle>Cancer Invest</addtitle><description>Beclin 1 physically associates with Bcl-xL and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-XL mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-XL expression in HCC may suggest cooperation in the regulation of apoptosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Autophagy</subject><subject>Bcl-X</subject><subject>bcl-X Protein - genetics</subject><subject>Beclin 1</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Female</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver Neoplasms - metabolism</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>Proliferating Cell Nuclear Antigen - genetics</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>Tumor suppressor</subject><issn>0735-7907</issn><issn>1532-4192</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rGzEQhkVJaZy0P6CXsKfcNhlpvJKX5BKbfIFpoR_QU8VYK8cK2pUj7ZL630fOx6GEkMvMwDzvMLwvY185HHGYwDEorFQNoIALkCjwAxvxCkU55rXYYaPtvsyA2mV7Kd0C8IlQ1Se2y5XkokYxYn-n1njXFbxof3w7K372MXQ3flPMQozWU29Tce_6VTE1vvwzf2TO_62jTcmFrsjCq6GlXO2a-mCs94OnWMwoGteFlj6zj0vyyX557vvs98X5r9lVOf9-eT07m5dOSOhLxMpUYy6EWshaKAHKIEwMEoGpCBtsCGrMA-do8nJsF1IYZRTyRdNIgfvs8OnuOoa7waZety5t36HOhiFpBbLGulLvgrxWIISUGTx4BodFaxu9jq6luNEv1mXg9Alw3TLElu5D9I3uaeNDXEbqjEsaOehtUvpVUll-8p98Zcn3K0PR6tswxC67pd9WPwCdBZR7</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Daniel, F.</creator><creator>Legrand, A.</creator><creator>Pessayre, D.</creator><creator>Borrega-Pires, F.</creator><creator>Mbida, L.</creator><creator>Lardeux, B.</creator><creator>Degott, C.</creator><creator>van Nhieu, J. Tran</creator><creator>Bernuau, D.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Beclin 1 mRNA Strongly Correlates with Bcl-XLmRNA Expression in Human Hepatocellular Carcinoma</title><author>Daniel, F. ; Legrand, A. ; Pessayre, D. ; Borrega-Pires, F. ; Mbida, L. ; Lardeux, B. ; Degott, C. ; van Nhieu, J. Tran ; Bernuau, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i260t-335c541227b6927207c308c3aa0c5a3d3da093a3d113c07c4eb62c7c731bdd623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Apoptosis Regulatory Proteins - genetics</topic><topic>Autophagy</topic><topic>Bcl-X</topic><topic>bcl-X Protein - genetics</topic><topic>Beclin 1</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Female</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver Neoplasms - metabolism</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>Proliferating Cell Nuclear Antigen - genetics</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>Tumor suppressor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daniel, F.</creatorcontrib><creatorcontrib>Legrand, A.</creatorcontrib><creatorcontrib>Pessayre, D.</creatorcontrib><creatorcontrib>Borrega-Pires, F.</creatorcontrib><creatorcontrib>Mbida, L.</creatorcontrib><creatorcontrib>Lardeux, B.</creatorcontrib><creatorcontrib>Degott, C.</creatorcontrib><creatorcontrib>van Nhieu, J. Tran</creatorcontrib><creatorcontrib>Bernuau, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daniel, F.</au><au>Legrand, A.</au><au>Pessayre, D.</au><au>Borrega-Pires, F.</au><au>Mbida, L.</au><au>Lardeux, B.</au><au>Degott, C.</au><au>van Nhieu, J. Tran</au><au>Bernuau, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beclin 1 mRNA Strongly Correlates with Bcl-XLmRNA Expression in Human Hepatocellular Carcinoma</atitle><jtitle>Cancer investigation</jtitle><addtitle>Cancer Invest</addtitle><date>2007-06</date><risdate>2007</risdate><volume>25</volume><issue>4</issue><spage>226</spage><epage>231</epage><pages>226-231</pages><issn>0735-7907</issn><eissn>1532-4192</eissn><abstract>Beclin 1 physically associates with Bcl-xL and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-XL mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-XL expression in HCC may suggest cooperation in the regulation of apoptosis.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>17612932</pmid><doi>10.1080/07357900701206323</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-7907 |
| ispartof | Cancer investigation, 2007-06, Vol.25 (4), p.226-231 |
| issn | 0735-7907 1532-4192 |
| language | eng |
| recordid | cdi_pubmed_primary_17612932 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Aged Aged, 80 and over Apoptosis Apoptosis Regulatory Proteins - genetics Autophagy Bcl-X bcl-X Protein - genetics Beclin 1 Carcinoma, Hepatocellular - metabolism Female Hepatocellular carcinoma Humans Liver Neoplasms - metabolism Male Membrane Proteins - genetics Middle Aged Proliferating Cell Nuclear Antigen - genetics Proto-Oncogene Proteins c-bcl-2 - genetics RNA, Messenger - analysis Tumor suppressor |
| title | Beclin 1 mRNA Strongly Correlates with Bcl-XLmRNA Expression in Human Hepatocellular Carcinoma |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T07%3A25%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Beclin%201%20mRNA%20Strongly%20Correlates%20with%20Bcl-XLmRNA%20Expression%20in%20Human%20Hepatocellular%20Carcinoma&rft.jtitle=Cancer%20investigation&rft.au=Daniel,%20F.&rft.date=2007-06&rft.volume=25&rft.issue=4&rft.spage=226&rft.epage=231&rft.pages=226-231&rft.issn=0735-7907&rft.eissn=1532-4192&rft_id=info:doi/10.1080/07357900701206323&rft_dat=%3Cproquest_pubme%3E70693957%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-i260t-335c541227b6927207c308c3aa0c5a3d3da093a3d113c07c4eb62c7c731bdd623%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=19702266&rft_id=info:pmid/17612932&rfr_iscdi=true |