POLYMORPHISMS OF ANDROGEN RECEPTOR GENE IN CHILDHOOD AND ADOLESCENT MALES WITH FIRST-ONSET MAJOR DEPRESSIVE DISORDER AND ASSOCIATION WITH RELATED SYMPTOMATOLOGY

This study was designed to explore the association between CAG repeats in AR gene and major depressive disorder (MDD) in male children and adolescents. The results showed that there were differences between adolescent depressive patients and adolescent controls in CAG repeats' length and allele...

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Bibliographic Details
Published in:International journal of neuroscience 2007-07, Vol.117 (7), p.903-917
Main Authors: SU, QIAO-RONG, SU, LIN-YAN, SU, HONG-RI, CHEN, QING, REN, GUANG-YUAN, YIN, YOU, SHEN, SHAO-QING, YU, AI-YUE, XIA, GUO-YUAN
Format: Article
Language:English
Subjects:
Adolescent
Age Distribution
CAG repeat
Case-Control Studies
Child
children
Chinese population
Depressive Disorder, Major - genetics
Depressive Disorder, Major - psychology
first-onset major depressive disorder
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Polymorphism, Genetic
Receptors, Androgen - genetics
Reference Values
Severity of Illness Index
Trinucleotide Repeats - genetics
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Summary:This study was designed to explore the association between CAG repeats in AR gene and major depressive disorder (MDD) in male children and adolescents. The results showed that there were differences between adolescent depressive patients and adolescent controls in CAG repeats' length and alleles' distributions, and the severity of depression and anxiety was negatively correlated with the length of CAG repeats in adolescent patients. This suggested that AR gene might be involved in the depressive upset in adolescents, and the age- and sex-related prevalent differences might also be associated to CAG repeats.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.1080/00207450600910689