Mutagenicity Testing of Mouthwash Brands

Several mouthwash brands were investigated for the evaluation of mutagenicity and cell-transforming activity in short-term mutagenicity test systems. The tests were: the Salmonella typhimurium mutagenicity assay (Ames tests), the unscheduled DNA-repair induction assay in primary rat hepatocytes (UDS...

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Bibliographic Details
Published in:Anticancer research 2007-07, Vol.27 (4A), p.2091-2098
Main Author: FRIEDRICH, R. E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
DNA Repair - drug effects
Fibroblasts - drug effects
Medical sciences
Mouthwashes - adverse effects
Mutagenesis - drug effects
Mutagenicity Tests
Otorhinolaryngology. Stomatology
Rats
Salmonella typhimurium - drug effects
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Several mouthwash brands were investigated for the evaluation of mutagenicity and cell-transforming activity in short-term mutagenicity test systems. The tests were: the Salmonella typhimurium mutagenicity assay (Ames tests), the unscheduled DNA-repair induction assay in primary rat hepatocytes (UDS-test), and the V79-HGPRT mutagenicity assay. Mouthwash, with and without an external metabolic activation system (S9), consistently showed no mutagenic or cytotoxic activity in the Ames test, UDS assay or the V79-HGPRT-assay. These results indicate that the tested mouthwash brands are unlikely to present a mutagenic or carcinogenic hazard. However, these findings derived from an in vitro study cannot imitate the situation in situ, where a plethora of pharmacologically or bio-chemically active agents pass the oral cavity, thereby reacting with each other and the oral mucosa, in particular when the use of such rinses occurs regularly over a long-term period.
ISSN:0250-7005
1791-7530