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Mutagenicity Testing of Mouthwash Brands
Several mouthwash brands were investigated for the evaluation of mutagenicity and cell-transforming activity in short-term mutagenicity test systems. The tests were: the Salmonella typhimurium mutagenicity assay (Ames tests), the unscheduled DNA-repair induction assay in primary rat hepatocytes (UDS...
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| Published in: | Anticancer research 2007-07, Vol.27 (4A), p.2091-2098 |
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| Format: | Article |
| Language: | English |
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| container_end_page | 2098 |
| container_issue | 4A |
| container_start_page | 2091 |
| container_title | Anticancer research |
| container_volume | 27 |
| creator | FRIEDRICH, R. E |
| description | Several mouthwash brands were investigated for the evaluation of mutagenicity and cell-transforming activity in short-term
mutagenicity test systems. The tests were: the Salmonella typhimurium mutagenicity assay (Ames tests), the unscheduled DNA-repair
induction assay in primary rat hepatocytes (UDS-test), and the V79-HGPRT mutagenicity assay. Mouthwash, with and without an
external metabolic activation system (S9), consistently showed no mutagenic or cytotoxic activity in the Ames test, UDS assay
or the V79-HGPRT-assay. These results indicate that the tested mouthwash brands are unlikely to present a mutagenic or carcinogenic
hazard. However, these findings derived from an in vitro study cannot imitate the situation in situ, where a plethora of pharmacologically
or bio-chemically active agents pass the oral cavity, thereby reacting with each other and the oral mucosa, in particular
when the use of such rinses occurs regularly over a long-term period. |
| format | article |
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mutagenicity test systems. The tests were: the Salmonella typhimurium mutagenicity assay (Ames tests), the unscheduled DNA-repair
induction assay in primary rat hepatocytes (UDS-test), and the V79-HGPRT mutagenicity assay. Mouthwash, with and without an
external metabolic activation system (S9), consistently showed no mutagenic or cytotoxic activity in the Ames test, UDS assay
or the V79-HGPRT-assay. These results indicate that the tested mouthwash brands are unlikely to present a mutagenic or carcinogenic
hazard. However, these findings derived from an in vitro study cannot imitate the situation in situ, where a plethora of pharmacologically
or bio-chemically active agents pass the oral cavity, thereby reacting with each other and the oral mucosa, in particular
when the use of such rinses occurs regularly over a long-term period.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17649827</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Animals ; Biological and medical sciences ; DNA Repair - drug effects ; Fibroblasts - drug effects ; Medical sciences ; Mouthwashes - adverse effects ; Mutagenesis - drug effects ; Mutagenicity Tests ; Otorhinolaryngology. Stomatology ; Rats ; Salmonella typhimurium - drug effects ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Anticancer research, 2007-07, Vol.27 (4A), p.2091-2098</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18913502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17649827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRIEDRICH, R. E</creatorcontrib><title>Mutagenicity Testing of Mouthwash Brands</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Several mouthwash brands were investigated for the evaluation of mutagenicity and cell-transforming activity in short-term
mutagenicity test systems. The tests were: the Salmonella typhimurium mutagenicity assay (Ames tests), the unscheduled DNA-repair
induction assay in primary rat hepatocytes (UDS-test), and the V79-HGPRT mutagenicity assay. Mouthwash, with and without an
external metabolic activation system (S9), consistently showed no mutagenic or cytotoxic activity in the Ames test, UDS assay
or the V79-HGPRT-assay. These results indicate that the tested mouthwash brands are unlikely to present a mutagenic or carcinogenic
hazard. However, these findings derived from an in vitro study cannot imitate the situation in situ, where a plethora of pharmacologically
or bio-chemically active agents pass the oral cavity, thereby reacting with each other and the oral mucosa, in particular
when the use of such rinses occurs regularly over a long-term period.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>DNA Repair - drug effects</subject><subject>Fibroblasts - drug effects</subject><subject>Medical sciences</subject><subject>Mouthwashes - adverse effects</subject><subject>Mutagenesis - drug effects</subject><subject>Mutagenicity Tests</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Rats</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpFzk1Lw0AUheFBFBurf0GyUdwE7nzPLGuxKrS4qevhJpkkI0lbMgml_95AK67O5uHwXpGEakszLTlckwSYhEwDyBm5i_EHQClr-C2ZUa2ENUwn5GUzDlj7XSjCcEq3Pg5hV6f7Kt3sx6E5YmzS1x53ZbwnNxW20T9cdk6-V2_b5Ue2_nr_XC7WWcM0DBkqo3ieS1BWcFXx0iA3SnifSwQDuqCUSquk8R5tAbqSRkjLtEaNXsiCz8nj-fcw5p0v3aEPHfYn95c8gacLwFhgW011RYj_zljKJbDJPZ9dE-rmGHrvYodtO91yhz3TTiwcgwn_AuKaVh4</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>FRIEDRICH, R. E</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20070701</creationdate><title>Mutagenicity Testing of Mouthwash Brands</title><author>FRIEDRICH, R. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-a6863bb5069436f3d8a3864eeb5a0807c11159658eea9c07f58459277a7ae45c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>DNA Repair - drug effects</topic><topic>Fibroblasts - drug effects</topic><topic>Medical sciences</topic><topic>Mouthwashes - adverse effects</topic><topic>Mutagenesis - drug effects</topic><topic>Mutagenicity Tests</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Rats</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRIEDRICH, R. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRIEDRICH, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagenicity Testing of Mouthwash Brands</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>27</volume><issue>4A</issue><spage>2091</spage><epage>2098</epage><pages>2091-2098</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Several mouthwash brands were investigated for the evaluation of mutagenicity and cell-transforming activity in short-term
mutagenicity test systems. The tests were: the Salmonella typhimurium mutagenicity assay (Ames tests), the unscheduled DNA-repair
induction assay in primary rat hepatocytes (UDS-test), and the V79-HGPRT mutagenicity assay. Mouthwash, with and without an
external metabolic activation system (S9), consistently showed no mutagenic or cytotoxic activity in the Ames test, UDS assay
or the V79-HGPRT-assay. These results indicate that the tested mouthwash brands are unlikely to present a mutagenic or carcinogenic
hazard. However, these findings derived from an in vitro study cannot imitate the situation in situ, where a plethora of pharmacologically
or bio-chemically active agents pass the oral cavity, thereby reacting with each other and the oral mucosa, in particular
when the use of such rinses occurs regularly over a long-term period.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17649827</pmid><tpages>8</tpages></addata></record> |
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| ispartof | Anticancer research, 2007-07, Vol.27 (4A), p.2091-2098 |
| issn | 0250-7005 1791-7530 |
| language | eng |
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| source | EZB Free E-Journals |
| subjects | Animals Biological and medical sciences DNA Repair - drug effects Fibroblasts - drug effects Medical sciences Mouthwashes - adverse effects Mutagenesis - drug effects Mutagenicity Tests Otorhinolaryngology. Stomatology Rats Salmonella typhimurium - drug effects Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Mutagenicity Testing of Mouthwash Brands |
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