The role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical cancer

• Published in: European journal of gynaecological oncology 2007, Vol.28 (4), p.290
• Main Authors: Türkçüoğlu, I, Tezcan, S, Kaygusuz, G, Atabekoğlu, C Somer, Ortaç, F, Güngör, M, Kankaya, D, Sertçelik, A
• Format: Article
• Language: English
• Subjects: Cervical Intraepithelial Neoplasia - classification; Cervical Intraepithelial Neoplasia - pathology; Female; Humans; Immunohistochemistry; Ki-67 Antigen - metabolism; Prognosis; Proto-Oncogene Proteins c-bcl-2 - metabolism; Tumor Suppressor Protein p53 - metabolism; Uterine Cervical Neoplasms - classification; Uterine Cervical Neoplasms - pathology
• ISSN: 0392-2936

The aim of this study was to determine the role of p53, Bcl-2 and Ki-67 expression in the carcinogenesis of cervical carcinoma and aggressiveness of cervical intraepithelial neoplasia (CIN). The pathology specimens of 63 patients with a diagnosis of normal squamous epithelium (22 cases), CIN I (14), CIN II (5), CIN III (8) and squamous cell carcinoma (14) were evaluated immunohistochemically for the expression of p53, Bcl-2 and Ki-67 in paraffin sections. The expression of p53 and Ki-67 increased proportionally to the grade of CIN and cervical cancer, but only the increase of p53 expression was statistically significant (p = 0.002). There was no significant correlation between Bcl-2 expression and premalignant and malignant cervical lesions. p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions.