Dillapiol and apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus

Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin Gsub(1) production. It inhibited aflatoxin Gsub(1) production by Aspergillus parasiticus with an ICsub(50) value of 0.15 microM without inhibiting aflatoxin Bsub(1) production or fungal growth. Apiol and myris...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-09, Vol.71 (9), p.2329-2332
Main Authors: Razzaghi-Abyaneh, M.(Tokyo Univ. (Japan)), Yoshinari, T, Shams-Ghahfarokhi, M, Rezaee, M.B, Nagasawa, H, Sakuda, S
Format: Article
Language:English
Subjects:
ACEITES ESENCIALES
aflatoxin
AFLATOXINAS
AFLATOXINE
AFLATOXINS
Aflatoxins - biosynthesis
Aflatoxins - chemistry
Allyl Compounds
ANETHUM GRAVEOLENS
apiol
AROMATIC COMPOUNDS
Aspergillus - chemistry
ASPERGILLUS PARASITICUS
Biological and medical sciences
BIOSINTESIS
BIOSYNTHESE
BIOSYNTHESIS
COMPOSE AROMATIQUE
COMPUESTOS AROMATICOS
dillapiol
Dioxoles - chemistry
ENZYME INHIBITORS
ESSENTIAL OILS
Fundamental and applied biological sciences. Psychology
HUILE ESSENTIELLE
INHIBIDORES DE ENZIMAS
INHIBITEUR D'ENZYME
inhibitor
Molecular Structure
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Summary:Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin Gsub(1) production. It inhibited aflatoxin Gsub(1) production by Aspergillus parasiticus with an ICsub(50) value of 0.15 microM without inhibiting aflatoxin Bsub(1) production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with ICsub(50) values of 0.24 and 3.5 microM, respectively.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.70264