Dramatic reduction of erythrocyte glucose-6-phosphate dehydrogenase activity in athletes participating in the ultradistance foot race "Spartathlon"

Objective. To investigate the effect of a long-distance endurance exercise "Spartathlon" on erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity. Material and methods. The study comprised 15 male runners, median age 36.5 years. Blood samples were obtained in the 15 min before the...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2008-01, Vol.68 (3), p.228-232
Main Authors: Schulpis, K. H., Tsironi, M., Skenderi, K., Lazaropoulou, C., Parthimos, N., Reclos, G., Goussetis, E., Tsakiris, S., Papassotiriou, I.
Format: Article
Language:English
Subjects:
Adult
Athletic Performance
Erythrocytes - enzymology
Exercise
Glucosephosphate Dehydrogenase - blood
Glucosephosphate Dehydrogenase - metabolism
glutathione
Humans
Lipid Peroxidation
Male
Middle Aged
NADP/NADPH
oxidation
Physical Endurance - physiology
Running - physiology
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Summary:Objective. To investigate the effect of a long-distance endurance exercise "Spartathlon" on erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity. Material and methods. The study comprised 15 male runners, median age 36.5 years. Blood samples were obtained in the 15 min before the race and again within 15 min after the end of the race. Erythrocyte glutathione (GSH and GSSG) and plasma malonyldialdehyde were measured with HPLC methods, and total antioxidant capacity (TAC), total hyperoxides and G6PD activity with commercial kits. Lipids, uric acid and total bilirubin were determined with a clinical chemistry analyser. Results. Total hyperoxides were found statistically reduced, whereas total bilirubin was measured elevated post-race. Interestingly, GSSG levels were found increased (167.3±12.0 versus 219.5±20.3 µmol L; p
ISSN:0036-5513
1502-7686
DOI:10.1080/00365510701604610