Adaptations of guest and host in expanded self-assembled capsules

Reversible encapsulation complexes create spaces where two or more molecules can be temporarily isolated. When the mobility of encapsulated molecules is restricted, different arrangements in space are possible, and new forms of isomerism ("social isomerism") are created: the orientation of...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (41), p.16000-16003
Main Authors: Ajami, Dariush, Rebek, Julius Jr
Format: Article
Language:English
Subjects:
Arachidonic Acids - chemistry
Benzene Derivatives - chemistry
Capsid Proteins - chemistry
Capsules
Cartoons
Chemical compounds
Chemistry
Drug Compounding
Encapsulating
Encapsulation
Fatty acids
Fatty Acids - chemistry
Hydrogen Bonding
Isomers
Magnetic Resonance Spectroscopy
Models, Chemical
Models, Molecular
Molecules
Omega 6 fatty acids
Physical Sciences
Proteins - chemistry
Social interaction
Solvents
Thermodynamics
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Summary:Reversible encapsulation complexes create spaces where two or more molecules can be temporarily isolated. When the mobility of encapsulated molecules is restricted, different arrangements in space are possible, and new forms of isomerism ("social isomerism") are created: the orientation of one encapsulated molecule influences that of the other in the confined space. Expansion of a capsule's length is possible through addition of small-molecule spacer elements. The expanded capsules have dimensions that permit the observation of social isomerism of two identical guests, and they adopt arrangements that properly fill the host's space. The host also can adapt to longer guests by incorporating additional spacers, much as protein modules are added to a viral capsid in response to larger genomes. Arachidonic and related fatty acid derivatives act in this way to induce the assembly of further extended capsules having sufficient length to accommodate them.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0707759104