Urinary catecholamines in children with attention deficit hyperactivity disorder (ADHD): Modulation by a polyphenolic extract from pine bark (Pycnogenol®)

Our study tested the hypothesis that treatment with a potent polyphenol complex not only reduces hyperactivity of children, but also catecholamine excretion and oxidative stress. Urine catecholamine concentrations were measured in attention deficit hyperactivity disorder (ADHD) children and healthy...

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Bibliographic Details
Published in:Nutritional neuroscience 2007-06, Vol.10 (3-4), p.151-157
Main Authors: Dvořáková, Monika, Ježová, Daniela, Blažíček, Pavol, Trebatická, Jana, Škodáček, Igor, Šuba, Ján, Waczulíková, Iveta, Rohdewald, Peter, Ďuračková, Zdeňka
Format: Article
Language:English
Subjects:
ADHD
Adolescent
ANTIOXIDANT
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - urine
CATECHOLAMINES
Catecholamines - urine
Child
Chromatography, High Pressure Liquid
Dietary Supplements
Dopamine - urine
Double-Blind Method
Epinephrine - urine
Female
Flavonoids - therapeutic use
GLUTATHIONE
Humans
Male
Norepinephrine - urine
OXIDATIVE STRESS
Phenols - therapeutic use
Pinus
Placebos
Plant Extracts - therapeutic use
Plant Stems
Polyphenols
PYCNOGENOLWREG
Reference Values
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Summary:Our study tested the hypothesis that treatment with a potent polyphenol complex not only reduces hyperactivity of children, but also catecholamine excretion and oxidative stress. Urine catecholamine concentrations were measured in attention deficit hyperactivity disorder (ADHD) children and healthy controls. ADHD children received either placebo (PL) or Pycnogenol ® (Pyc), a bioflavonoid extract from the pine bark, for one month. The study was performed in a randomized, double-blind, PL controlled design. Concentrations of catecholamines were higher in urine of ADHD patients compared to those of healthy children. Moreover, noradrenaline (NA) concentrations positively correlated with degree of hyperactivity of ADHD children. In ADHD patients, adrenaline (A) and NA concentrations positively correlated with plasma levels of oxidized glutathione. The treatment of ADHD children with Pyc caused decrease of dopamine (D) and trend of A and NA decrase and increased GSH/GSSG ratio. In conclusion, the data provide further evidence for the overactivity of the noradrenergic system in ADHD and demonstrate that A release may be increased, as well. Treatment of ADHD children with Pyc normalized catecholamine concentrations, leading to less hyperactivity, and, consequently, to reduced oxidative stress.
ISSN:1028-415X
1476-8305
DOI:10.1080/09513590701565443