Comedogenicity in Rabbit: Some Cosmetic Ingredients Vehicles

The rabbit external ear canal was used to define which chemicals caused comedone formation on topical application. Some of the tested ingredients are currently used in topically applied formulations. Certain raw materials have been shown to produce follicular hyperkeratosis in the rabbit ear assay....

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Bibliographic Details
Published in:Cutaneous and ocular toxicology 2007-01, Vol.26 (4), p.287-292
Main Authors: Nguyen, Shawn H., Dang, Thao P., Maibach, Howard I.
Format: Article
Language:English
Subjects:
Acne
Acne Vulgaris - chemically induced
Animals
Biological and medical sciences
Butyl stearate
Cocoa butter
Comedogenicity
Comedones
Cosmetics - toxicity
Decyl oleate
Dermatology
Domestic and cosmetic products toxicology
Dose-Response Relationship, Drug
Female
Hair and nails disorders
Isocetyl stearate
Isopropyl isostearate
Isopropyl myristate
Isopropyl neopentanoate
Isopropyl palmitate
Male
Medical sciences
Myristyl myristate
Rabbit
Rabbits
Skin
Skin involvement in other diseases. Miscellaneous. General aspects
Skin Tests
Toxicology
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Summary:The rabbit external ear canal was used to define which chemicals caused comedone formation on topical application. Some of the tested ingredients are currently used in topically applied formulations. Certain raw materials have been shown to produce follicular hyperkeratosis in the rabbit ear assay. This study quantifies comedogenic potential of cosmetic materials, including: isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristle myristate, cocoa butter, cetyl alcohol, paraffin, stearyl alcohol sodium lauryl sulfate (SLS), and petrolatum. The first nine were deemed positive. Factors aiding clinical relevance are listed.
ISSN:1556-9527
1556-9535
DOI:10.1080/15569520701555383