Paracoccidioidomycosis of intramedullar and cerebral localization

It is reported our diagnosis and therapeutical experience with a patient that presented clinical, radiological and tomographical manifestations of paracoccidioidomycosis with involvement of lungs, brain and spinal cord. Besides being a rare case the authors call attention for the extreme difficulty...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 1991-06, Vol.49 (2), p.192
Main Authors: Morato-Fernandez, R N, Beraldo, P S, Masini, M, Costa, P H
Format: Article
Language:Portuguese
Subjects:
Central Nervous System Diseases - diagnosis
Central Nervous System Diseases - drug therapy
Humans
Ketoconazole - therapeutic use
Male
Middle Aged
Paracoccidioidomycosis - diagnosis
Paracoccidioidomycosis - drug therapy
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Summary:It is reported our diagnosis and therapeutical experience with a patient that presented clinical, radiological and tomographical manifestations of paracoccidioidomycosis with involvement of lungs, brain and spinal cord. Besides being a rare case the authors call attention for the extreme difficulty in defining the final diagnosis, which was achieved only after laminectomy and surgical biopsy of the intra spinal cord tumor at the C5 level. The patient received two series of treatment with ketoconazole (400-600 mg/day). After both the patient presented tonic and clonic convulsive disorders. We speculated about a possible perigranulomatous inflammatory response related to the therapeutical intervention, not yet described in literature.
ISSN:0004-282X