Incidence and clinical features of pituitary tumours in cases of central Cushing's syndrome (author's transl)

Approximately 10% of all patients with untreated central Cushing's syndromes have clinically verifiable tumours of the pituitary. After bilateral adrenalectomy 10 to 20% of patients with apparently normal pre-operative pituitary glands develop clinically and roentgenologically demonstrable pitu...

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Bibliographic Details
Published in:Acta neurochirurgica 1976, Vol.33 (3-4), p.241
Main Author: Barwich, D
Format: Article
Language:ger
Subjects:
Adenoma - drug therapy
Adenoma - physiopathology
Adenoma, Chromophobe - complications
Adrenocorticotropic Hormone - metabolism
Adult
Cortisone - therapeutic use
Cushing Syndrome - complications
Cushing Syndrome - drug therapy
Cushing Syndrome - physiopathology
Female
Humans
Melanocyte-Stimulating Hormones - metabolism
Pituitary Neoplasms - complications
Pituitary Neoplasms - drug therapy
Pituitary Neoplasms - physiopathology
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Summary:Approximately 10% of all patients with untreated central Cushing's syndromes have clinically verifiable tumours of the pituitary. After bilateral adrenalectomy 10 to 20% of patients with apparently normal pre-operative pituitary glands develop clinically and roentgenologically demonstrable pituitary tumours, of the so called Nelson type. These are usually very active chromophobe adenomas which are dangerous because they expand rapidly. They secretee considerable amounts of ACTH and MSH. A typical case is described.
ISSN:0001-6268
DOI:10.1007/BF01886673