Iron Chelators and Free Radical Scavengers in Naturally Occurring Polyhydroxylated 1,4-Naphthoquinones

The cardioprotective effect of polyhydroxylated 1,4-naphthoquinones on the experimental model of myocardial ischemia-reperfusion has been demonstrated previously. In this study, using different models, such as bulk organic phase, liposomes and sarcoplasmic reticulum (SR) vesicles, we have shown the...

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Bibliographic Details
Published in:Hemoglobin 2008, Vol.32 (1-2), p.165-179
Main Authors: Lebedev, Alexander V., Ivanova, Marina V., Levitsky, Dmitri O.
Format: Article
Language:English
Subjects:
Acid-base properties
Animals
Antioxidant(s)
Biochemistry
Biochemistry, Molecular Biology
Calcium - metabolism
Cardioprotection
Free Radical Scavengers - metabolism
Free Radical Scavengers - pharmacology
Hemin - metabolism
Hydrogen-Ion Concentration
Iron - metabolism
Iron Chelating Agents - chemistry
Iron Chelating Agents - metabolism
Iron Chelating Agents - pharmacology
Iron chelators
Ischemia-reperfusion
Life Sciences
Liposomes - metabolism
Muscle, Skeletal - metabolism
Naphthoquinones - chemistry
Naphthoquinones - metabolism
Naphthoquinones - pharmacology
Oxidation-Reduction
Polyhydroxy-1,4-naphthoquinones (PHNQs)
Rabbits
Sarcoplasmic Reticulum - drug effects
Sarcoplasmic Reticulum - metabolism
Superoxides - metabolism
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Summary:The cardioprotective effect of polyhydroxylated 1,4-naphthoquinones on the experimental model of myocardial ischemia-reperfusion has been demonstrated previously. In this study, using different models, such as bulk organic phase, liposomes and sarcoplasmic reticulum (SR) vesicles, we have shown the ability of naturally occurring polyhydroxynaphthoquinones, echinochrome (Ech), spinochromes C, D and E (SpC, SpD and SpE) to inhibit free-radical oxidation induced by heme iron (hemin) or by free iron ions (in ferrous ascorbate system). The polyhydroxy-1,4-naphthoquinones (PHNQs) were more effective in inhibiting the phosphatidyl choline liposome peroxidation induced by ferrous ascorbate than that induced by hemin. The iron chelating ability of PHNQs was determined spectrophotometrically. Prevention of the ferrous ascorbate-induced leakage of calcium by Ech was demonstrated in isolated SR vesicles from rabbit skeletal muscle. The PHNQs displayed high scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. We concluded that iron chelation predominates in the overall antioxidant potential of the polyhydroxynaphthoquinones.
ISSN:0363-0269
1532-432X
DOI:10.1080/03630260701700017