Nicorandil-induced cutaneous ulceration on a pacemaker implantation wound

Nicorandil is a potassium-channel activator used to prevent angina. While mucosal ulceration is a well-known adverse effect of this drug, skin ulcers have been described only rarely, and always in association with mucosal ulcers. An 86-year-old woman presented ulceration on a pacemaker implantation...

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Bibliographic Details
Published in:Annales de dermatologie et de vénéréologie 2008-02, Vol.135 (2), p.131
Main Authors: Jennesseaux, I, Carre-Gislard, D, Bravard, P
Format: Article
Language:fre
Subjects:
Aged, 80 and over
Anti-Arrhythmia Agents - adverse effects
Cicatrix - pathology
Conjunctivitis - chemically induced
Female
Follow-Up Studies
Humans
Nicorandil - adverse effects
Pacemaker, Artificial
Skin Ulcer - chemically induced
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Summary:Nicorandil is a potassium-channel activator used to prevent angina. While mucosal ulceration is a well-known adverse effect of this drug, skin ulcers have been described only rarely, and always in association with mucosal ulcers. An 86-year-old woman presented ulceration on a pacemaker implantation scar despite complete initial wound healing. Nicorandil had been initiated three months earlier. None of the usual causes of ulceration of a pacemaker scar were seen. Complete and permanent wound-healing was achieved 12 days after discontinuation of nicorandil. This is the first reported case of cutaneous ulceration on a vulnerable area of skin ascribable to high-dose nicorandil.
ISSN:0151-9638
DOI:10.1016/j.annder.2007.06.008