Transient neonatal hypothyroidism due to amiodarone administration during pregnancy--two cases report and review of literature

Amiodarone (AMD) is an antiarrhythmic agent which contains 37% of iodine. It can reach the fetus by transplacental passage and induce transient congenital hypothyroidism (TCH). We report two cases of TCH caused by gestational exposure to AMD, detected by the Newborn Screening Program for Congenital...

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Bibliographic Details
Published in:Arquivos brasileiros de endocrinologia e metabologia 2008-02, Vol.52 (1), p.126
Main Authors: Pavan-Senn, Carla C, Nesi-França, Suzana, Pelaez, Julita, Pereira, Rosana M, Boguszewski, Margaret C da S, Sandrini Neto, Romolo, Lacerda Filho, Luiz de
Format: Article
Language:Portuguese
Subjects:
Amiodarone - adverse effects
Anti-Arrhythmia Agents - adverse effects
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Congenital Hypothyroidism - chemically induced
Congenital Hypothyroidism - psychology
Female
Humans
Infant, Newborn
Intelligence
Pregnancy
Thyroid Function Tests
Thyroid Gland - drug effects
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Summary:Amiodarone (AMD) is an antiarrhythmic agent which contains 37% of iodine. It can reach the fetus by transplacental passage and induce transient congenital hypothyroidism (TCH). We report two cases of TCH caused by gestational exposure to AMD, detected by the Newborn Screening Program for Congenital Hypothyroidism of the State of Paraná-Brazil. CLINICAL CASE 1 (C1): Neonatal TSH value was 78.2 mU/L (normal
ISSN:0004-2730
DOI:10.1590/S0004-27302008000100018