Muscling in on microarrays

Adaptations that are the result of exercise require a multitude of changes at the level of gene expression. The mechanisms involved in regulating these changes are many, and can occur at various points in the pathways that affect gene expression. The completion of the human genome sequence, along wi...

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Bibliographic Details
Published in:Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2008-02, Vol.33 (1), p.124-129
Main Authors: Virtanen, Carl, Takahashi, Mark
Format: Article
Language:English
Subjects:
Animals
ARN
Exercise
Exercise - physiology
expression génétique
Gene expression
Genes
genomic sequence
Genomics
Genomics - trends
high throughput
Humans
Metabolism
microarrays
micropuces
Muscle, Skeletal - physiology
next generation
nouvelle génération
Oligonucleotide Array Sequence Analysis - trends
Ribonucleic acid
RNA
séquence génomique
à grande échelle
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Summary:Adaptations that are the result of exercise require a multitude of changes at the level of gene expression. The mechanisms involved in regulating these changes are many, and can occur at various points in the pathways that affect gene expression. The completion of the human genome sequence, along with the genomes of related species, has provided an enormous amount of information to help dissect and understand these pathways. High-throughput methods, such as DNA microarrays, were the first on the scene to take advantage of this wealth of information. A new generation of microarrays has now taken the next step in revealing the mechanisms controlling gene expression. Analysis of the regulation of gene expression can now be profiled in a high-throughput fashion. However, the application of this technology has yet to be fully realized in the exercise physiology community. This review will highlight some of the latest advances in microarrays and briefly discuss some potential applications to the field of exercise physiology.
ISSN:1715-5312
1715-5320
DOI:10.1139/H07-150