Reversible posterior leukoencephalopathy: report of two cases after vincristine treatment

Reversible posterior leukoencephalopathy syndrome is a clinical-radiological phenomenon associated with headache, vomiting, lethargy, visual disturbances and seizures, concomitant with radiological abnormalities predominantly within posterior cerebral white matter due to cerebral edema. There are mu...

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Bibliographic Details
Published in:Anales de pediatría (Barcelona, Spain : 2003) Spain : 2003), 2008-03, Vol.68 (3), p.282
Main Authors: Hualde Olascoaga, J, Molins Castiella, T, Souto Hernández, S, Becerril Moreno, F, Yoldi Petri, M E, Sagaseta de Ilurdoz, M, Molina Garicano, J
Format: Article
Language:Spanish
Subjects:
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
Child
Female
Humans
Posterior Leukoencephalopathy Syndrome - chemically induced
Posterior Leukoencephalopathy Syndrome - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
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Summary:Reversible posterior leukoencephalopathy syndrome is a clinical-radiological phenomenon associated with headache, vomiting, lethargy, visual disturbances and seizures, concomitant with radiological abnormalities predominantly within posterior cerebral white matter due to cerebral edema. There are multiple triggers as acute hypertension, cancer, hematological disease, renal pathology, red cells transfusions and different drugs. We present two patients with reversible posterior leukoencephalopathy under treatment for acute lymphoblastic leukemia because of the probable association with vinca alkaloids.
ISSN:1695-4033