Plasma homocysteine levels in patients with β-thalassaemia major

Objective. We investigated the level of homocysteine (HCY) and its relation with vitamin B12, folate and oxidative stress in patients with β-thalassaemia major. Material and methods. Plasma HCY, methionine, advanced oxidation protein products (AOPP) and serum vitamin B12, folate, ferritin and total...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2008-01, Vol.68 (2), p.134-139
Main Authors: Ozdem, S., Kupesiz, A., Yesilipek, A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
beta-Thalassemia - blood
Female
Folic acid
homocysteine
Homocysteine - blood
Humans
Male
Oxidative Stress
thalassaemia
vitamin B12
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Summary:Objective. We investigated the level of homocysteine (HCY) and its relation with vitamin B12, folate and oxidative stress in patients with β-thalassaemia major. Material and methods. Plasma HCY, methionine, advanced oxidation protein products (AOPP) and serum vitamin B12, folate, ferritin and total antioxidant capacity (TAC) were determined in 32 thalassaemic patients and 27 control subjects. Results. HCY (6.44±0.44 versus 8.71±0.57 µmol/L), methionine (12.57±1.8 versus 22.2±3.8 µmol/L), folate (9.14±0.48 versus 15.38±0.71 nmol/L) and TAC (0.34±0.03 versus 0.56±0.03 mmol/L) significantly decreased in thalassaemic patients, whereas AOPP (20.26±1.8 versus 11.30±0.2 μmol/L) and ferritin (3481.0±512 versus 46.9±4.6 ng/mL) significantly increased. Vitamin B12 levels were similar in both groups (259.1±16.6 versus 228.9±7.4 pmol/L). Conclusions. These findings suggest that increased and uncompensated oxidative stress may lead to an increment in HCY catabolism in thalassaemic patients.
ISSN:0036-5513
1502-7686
DOI:10.1080/00365510701516343