Ameliorative action of cyanobacterial phycoerythrin on CCl(4)-induced toxicity in rats

Carbon tetrachloride (CCl(4)) is largely used as solvent in chemical industries. Carbon tetrachloride is also well known for hepatic and renal toxic actions. The in vivo metabolism of carbon tetrachloride to trichloromethyl (CCl(3)) and peroxy trichloromethyl (OOCCl(3)) radicals has been extensively...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology (Amsterdam) 2008-06, Vol.248 (1), p.59
Main Authors: Soni, Badrish, Visavadiya, Nishant P, Madamwar, Datta
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Carbon Tetrachloride - toxicity
Cyanobacteria - chemistry
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
Organ Size - drug effects
Oxidative Stress - drug effects
Phycoerythrin - pharmacology
Protective Agents - pharmacology
Rats
Solvents - toxicity
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Carbon tetrachloride (CCl(4)) is largely used as solvent in chemical industries. Carbon tetrachloride is also well known for hepatic and renal toxic actions. The in vivo metabolism of carbon tetrachloride to trichloromethyl (CCl(3)) and peroxy trichloromethyl (OOCCl(3)) radicals has been extensively reported to cause acute liver damage like cirrhosis, steatosis and necrosis. We have evaluated protective action of purified cyanobacterial phycoerythrin (C-PE) on carbon tetrachloride-induced hepatic and renal toxicity in male rats. Rats were orally treated with 25 and 50mg/kg BW of C-PE along with CCl(4) (50% CCl(4), 0.5 ml/kg BW, intraperitoneally) for 28 consecutive days. Results demonstrated that C-PE dose-responsively ameliorates CCl(4)-toxicity by significantly decreasing (P
ISSN:0300-483X
DOI:10.1016/j.tox.2008.03.008