Expression of NK cells activation receptors after occupational exposure to toxics: a preliminary study

The expression of NK cells activation receptors was assessed by comparative study of two groups of women workers at a chemical reagents factory, located in Zapopan, Jalisco, Mexico. Twenty of them were exposed to environmental toxics identified and quantified by gas chromatography, and 20 women unex...

Full description

Saved in:
Bibliographic Details
Published in:Immunology letters 2008-06, Vol.118 (2), p.125
Main Authors: De Celis, Ruth, Feria-Velasco, Alfredo, Bravo-Cuellar, Alejandro, Hicks-Gómez, Juan José, García-Iglesias, Trinidad, Preciado-Martínez, Verónica, Muñoz-Islas, Laura, González-Unzaga, Marco
Format: Article
Language:English
Subjects:
Adult
Antioxidants - metabolism
Chemical Industry
Environmental Pollutants - toxicity
Female
Gene Expression Regulation - drug effects
Halogens - analysis
Halogens - toxicity
Humans
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Lymphocyte Activation - drug effects
Mexico
Middle Aged
Occupational Exposure
Organic Chemicals - analysis
Organic Chemicals - toxicity
Receptors, Natural Killer Cell - drug effects
Receptors, Natural Killer Cell - immunology
Thiobarbituric Acid Reactive Substances - metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The expression of NK cells activation receptors was assessed by comparative study of two groups of women workers at a chemical reagents factory, located in Zapopan, Jalisco, Mexico. Twenty of them were exposed to environmental toxics identified and quantified by gas chromatography, and 20 women unexposed to toxic substances. The expression of the surface markers CD56+ and CD3+, and of the activation receptors and co-receptors on NK cells was quantified by flow cytometry. To assess the cellular damage produced by chronic exposure to the toxics, the thiobarbituric acid reacting substances (TBARS) generated and the total plasma antioxidizing capacity (TPAC) were quantified in both groups. The exposed women had been exposed at least to 12 volatile toxic compounds, benzene, benz(a)pyrene, ethylbenzene, dimethylbenz(a)anthracene, xylene, toluene, styrene, chloroform, formaldehyde, iodine, chlorine and fluorine. Significant difference between the two groups was in the proportion of CD3 lymphocytes, 72.7+/-10.3% in the unexposed women versus 66.8+/-7.9% in the exposed group (p
ISSN:0165-2478
DOI:10.1016/j.imlet.2008.03.010