Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-microm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry

A quantitative multiresidue method covering more than 100 veterinary drugs, belonging to different drug families, has been developed. The proposed approach uses an liquid-liquid-solid extraction technique (bi-polarity extraction) which is capable in recovering polar, medium polar and apolar compound...

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Bibliographic Details
Published in:Journal of chromatography. A 2008-06, Vol.1194 (1), p.66
Main Authors: Kaufmann, Anton, Butcher, Patrick, Maden, Kathryn, Widmer, Mirjam
Format: Article
Language:English
Subjects:
Animals
Chromatography, High Pressure Liquid - methods
Drug Residues - analysis
Mass Spectrometry - methods
Meat Products - analysis
Particle Size
Reference Standards
Veterinary Medicine
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Summary:A quantitative multiresidue method covering more than 100 veterinary drugs, belonging to different drug families, has been developed. The proposed approach uses an liquid-liquid-solid extraction technique (bi-polarity extraction) which is capable in recovering polar, medium polar and apolar compounds. A thorough generic reversed phase solid-phase extraction (SPE) clean-up removes interfering proteins and provides clean and stable extracts. Dedicated rinsing steps are proposed to reduce analyte adsorption on glass walls and on precipitating proteins. The resulting extract is analyzed by ultra-performance liquid chromatography (UPLC) coupled to time of flight mass spectrometry (TOF). The method was validated according to the Commission Decision 2002/657/EEC. Validation coved the relevant meat matrices (muscle, kidney and liver).
ISSN:0021-9673
DOI:10.1016/j.chroma.2008.03.089