Prevalence of Toxic Shock Syndrome Toxin 1 (TSST-1)-Producing Strains of Staphylococcus aureus and Antibody to TSST-1 among Healthy Japanese Women

Many cases of neonatal toxic shock syndrome (TSS)-like exanthematous disease but few cases of menstrual TSS (mTSS) have been reported in Japan. We determined the prevalence of mucosal colonization with Staphylococcus aureus and of positive antibodies to TSS toxin 1 (TSST-1) among 209 healthy Japanes...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Clinical Microbiology 2008-08, Vol.46 (8), p.2731-2738
Main Authors: Parsonnet, Jeffrey, Goering, Richard V, Hansmann, Melanie A, Jones, Michaelle B, Ohtagaki, Kumiko, Davis, Catherine C, Totsuka, Kyoichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Bacterial - blood
Bacterial Toxins - biosynthesis
Bacteriology
Biological and medical sciences
Carrier State - epidemiology
Carrier State - immunology
Carrier State - microbiology
Cluster Analysis
DNA Fingerprinting
DNA, Bacterial - genetics
Electrophoresis, Gel, Pulsed-Field
Enterotoxins - biosynthesis
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genotype
Humans
Microbiology
Middle Aged
Miscellaneous
Prevalence
Sequence Analysis, DNA - methods
Seroepidemiologic Studies
Staphylococcus aureus - classification
Staphylococcus aureus - enzymology
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
Superantigens - biosynthesis
Tokyo - epidemiology
United States - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many cases of neonatal toxic shock syndrome (TSS)-like exanthematous disease but few cases of menstrual TSS (mTSS) have been reported in Japan. We determined the prevalence of mucosal colonization with Staphylococcus aureus and of positive antibodies to TSS toxin 1 (TSST-1) among 209 healthy Japanese women in Tokyo. S. aureus isolates from mucosal sites were characterized with respect to TSST-1 production and resistance genotype. Antibody titers were determined for test subjects and for 133 Japanese and 137 Caucasian control women living in the United States. S. aureus was isolated from at least one site in 108 of 209 women (52%) in Tokyo. Of the 159 S. aureus isolates recovered, 14 (9%) were TSST-1 positive (12 unique strains). Twelve of 209 women (6%) were colonized with a TSST-1-producing strain; two (
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00228-08