Deinococcus radiodurans: What Belongs to the Survival Kit?

Deinococcus radiodurans, one of the most radioresistant organisms known to date, is able to repair efficiently hundreds of DNA double- and single-strand breaks as well as other types of DNA damages promoted by ionizing or ultraviolet radiation. We review recent discoveries concerning several aspects...

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Bibliographic Details
Published in:Critical reviews in biochemistry and molecular biology 2008-05, Vol.43 (3), p.221-238
Main Authors: Blasius, Melanie, Hübscher, Ulrich, Sommer, Suzanne
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Deinococcus - cytology
Deinococcus - genetics
Deinococcus - metabolism
Deinococcus - radiation effects
Deinococcus radiodurans
Desiccation
DNA repair
DNA Repair - radiation effects
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
DNA, Bacterial - metabolism
DNA, Bacterial - radiation effects
Genome, Bacterial - genetics
Genome, Bacterial - radiation effects
Life Sciences
Microbial Viability - radiation effects
Microbiology and Parasitology
oxidative stress
radiation resistance
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Summary:Deinococcus radiodurans, one of the most radioresistant organisms known to date, is able to repair efficiently hundreds of DNA double- and single-strand breaks as well as other types of DNA damages promoted by ionizing or ultraviolet radiation. We review recent discoveries concerning several aspects of radioresistance and survival under high genotoxic stress. We discuss different hypotheses and possibilities that have been suggested to contribute to radioresistance and propose that D. radiodurans combines a variety of physiological tools that are tightly coordinated. A complex network of regulatory proteins may be discovered in the near future that might allow further understanding of radioresistance.
ISSN:1040-9238
1549-7798
DOI:10.1080/10409230802122274