A clinical trial examining the effect of increased total CRM(197) carrier protein dose on the antibody response to Haemophilus influenzae type b CRM(197) conjugate vaccine

CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in additio...

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Bibliographic Details
Published in:Vaccine 2008-08, Vol.26 (35), p.4602
Main Authors: Usonis, Vytautas, Bakasenas, Vytautas, Lockhart, Stephen, Baker, Sherryl, Gruber, William, Laudat, France
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - blood
Bacterial Proteins - adverse effects
Bacterial Proteins - immunology
Diphtheria Toxoid - administration & dosage
Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage
Drug Interactions
Female
Haemophilus Vaccines - administration & dosage
Haemophilus Vaccines - adverse effects
Haemophilus Vaccines - immunology
Humans
Infant
Male
Meningococcal Vaccines - administration & dosage
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Summary:CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria toxoid/tetanus toxoid/acellular pertussis vaccine (DTaP) received either diphtheria CRM(197)-based Haemophilus influenzae type b conjugate vaccine (HbOC) or HbOC and a diphtheria CRM(197)-based combination 9-valent pneumococcal conjugate vaccine/meningococcal group C conjugate vaccine. Administration of conjugate vaccines with CRM(197) carrier protein load >50 microg did not reduce response to CRM(197) conjugate vaccines or immunogenicity to immunologically cross-reactive diphtheria toxoid.
ISSN:0264-410X
DOI:10.1016/j.vaccine.2008.05.087