Weekly docetaxel vs. docetaxel-based combination chemotherapy as second-line treatment of advanced non-small-cell lung cancer patients The DISTAL-2 randomized trial

Doublet chemotherapy is more effective than single-agent as first line treatment of advanced non-small-cell lung cancer (NSCLC). No reliable information instead is available on the effect of doublets in second line treatment. The aim of DISTAL-2 study was to compare two doublets containing docetaxel...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2009-02, Vol.63 (2), p.251-258
Main Authors: GEBBIA, Vittorio, GRIDELLI, Cesare, PERRONE, Francesco, MORABITO, Alessandro, VERUSIO, Claudio, FRONTINI, Luciano, AITINI, Enrico, DANIELE, Bruno, GAMUCCI, Teresa, MANCUSO, Gianfranco, DI MAIO, Massimo, GALLO, Ciro
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - psychology
Female
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - mortality
Lung Neoplasms - psychology
Male
Medical sciences
Medication Adherence
Middle Aged
Pneumology
Quality of Life
Survival Rate
Taxoids - administration & dosage
Tumors
Tumors of the respiratory system and mediastinum
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Summary:Doublet chemotherapy is more effective than single-agent as first line treatment of advanced non-small-cell lung cancer (NSCLC). No reliable information instead is available on the effect of doublets in second line treatment. The aim of DISTAL-2 study was to compare two doublets containing docetaxel with single agent docetaxel as second line treatment of patients with NSCLC (ClinicalTrials.gov id.:.NCT00345059). NSCLC patients, aged
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2008.05.027