Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin

The WXYZA'B'C' ring system ( 1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C' ring fragments through construction of the XY and A'B' ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by...

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Bibliographic Details
Published in:Organic letters 2008-08, Vol.10 (16), p.3599
Main Authors: Oishi, Tohru, Hasegawa, Futoshi, Torikai, Kohei, Konoki, Keiichi, Matsumori, Nobuaki, Murata, Michio
Format: Article
Language:English
Subjects:
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Erythrocytes - drug effects
Hemolysis - drug effects
Humans
Magnetic Resonance Spectroscopy - methods
Marine Toxins - chemical synthesis
Marine Toxins - chemistry
Marine Toxins - pharmacology
Molecular Conformation
Oxocins - chemical synthesis
Oxocins - chemistry
Oxocins - pharmacology
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Summary:The WXYZA'B'C' ring system ( 1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C' ring fragments through construction of the XY and A'B' ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by MTX.
ISSN:1523-7052
DOI:10.1021/ol801369g