Effects of Dehydroepiandrosterone Sulfate and Progesterone on Spatial Learning and Memory in Young and Aged Mice

Young (2-4 months) and aged (14-16 months) male Swiss-Webster albino mice (n = 7 per group) were subcutaneously injected with 20 mg/kg/day dehydroepiandrosterone sulfate (DHEAS), progesterone (P), DHEAS + P, or vehicle control and trained over a 5-day period in a Morris water maze. The subjects were...

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Bibliographic Details
Published in:The Journal of general psychology 2008-07, Vol.135 (3), p.271-286
Main Authors: Bodensteiner, Karin J., Stone, Ivan J., Ghiraldi, Loraina L.
Format: Article
Language:English
Subjects:
Adult. Elderly
Age
Age groups
Aging
Aging - drug effects
Albinism
Alzheimer's disease
Animal cognition
Animal memory
Animals
Behavioral psychophysiology
Biological and medical sciences
Cognitive ability
dehydroepiandrosterone sulfate
Dehydroepiandrosterone Sulfate - pharmacology
Developmental psychology
Drug Interactions
Escape Reaction - drug effects
Fundamental and applied biological sciences. Psychology
Hormone replacement therapy
Hormones and behavior
Male
Maze Learning - drug effects
Memory
Mental Recall - drug effects
Mice
Orientation - drug effects
progesterone
Progesterone - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reaction Time - drug effects
Researchers
Retention
Retention (Psychology) - drug effects
Rodents
spatial memory
Studies
Women
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Description
Summary:Young (2-4 months) and aged (14-16 months) male Swiss-Webster albino mice (n = 7 per group) were subcutaneously injected with 20 mg/kg/day dehydroepiandrosterone sulfate (DHEAS), progesterone (P), DHEAS + P, or vehicle control and trained over a 5-day period in a Morris water maze. The subjects were tested 48 hr after training for memory recall as measured by latencies to locate the hidden platform, and trunk blood was collected immediately thereafter. As expected, latency to platform decreased for all groups over the 6 testing days, with aged mice taking longer to reach platform than did young mice. However, results did not support the hypotheses that DHEAS-treated mice would exhibit shorter latencies and that P-treated mice would show longer latencies to platform in comparison with age-matched controls. These results raise doubts about the effectiveness of commercially available supplements claiming to promote enhanced memory in humans.
ISSN:0022-1309
1940-0888
DOI:10.3200/GENP.135.3.271-286