Effect of strontium in combination with fluoride on enamel remineralization in vitro

• Published in: Archives of oral biology 2008-11, Vol.53 (11), p.1017
• Main Authors: Thuy, Tran Thu, Nakagaki, Haruo, Kato, Kazuo, Hung, Phan Ai, Inukai, Junko, Tsuboi, Shinji, Nakagaki, Hidetaka, Hirose, Mina N, Igarashi, Seiji, Robinson, Colin
• Format: Article
• Language: English
• Subjects: Bicuspid - drug effects; Bicuspid - metabolism; Bicuspid - pathology; Dental Enamel - drug effects; Dental Enamel - metabolism; Dental Enamel - pathology; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Fluorides, Topical - pharmacology; Humans; In Vitro Techniques; Microradiography; Minerals - metabolism; Strontium - pharmacology; Tooth Demineralization - metabolism; Tooth Demineralization - pathology; Tooth Remineralization - methods
• ISSN: 1879-1506
• DOI: 10.1016/j.archoralbio.2008.06.005

Previous studies showed that strontium (Sr) as well as fluoride (F) can enhance enamel remineralization. The aim of this study was to evaluate the effects of Sr in combination with F on enamel remineralization in vitro. Sixty enamel specimens obtained from caries free human premolars were demineralised to produce caries-like lesions. Half of each lesion was covered with nail varnish as an untreated control. The specimens were then randomly divided into F and Sr+F treatment groups. The F group was exposed to remineralizing solutions (1.5mM CaCl(2), 0.9 mM KH(2)PO(4)) containing 1 ppm, 0.1 ppm or 0.05 ppm F. The Sr+F treatment group was exposed to the same solutions including 10 ppm Sr. After 2 weeks, lesion depth, mineral loss and percentage enamel remineralization were determined using transversal microradiography. There was a significant decrease in mineral loss in all groups (p