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Effect of strontium in combination with fluoride on enamel remineralization in vitro
Previous studies showed that strontium (Sr) as well as fluoride (F) can enhance enamel remineralization. The aim of this study was to evaluate the effects of Sr in combination with F on enamel remineralization in vitro. Sixty enamel specimens obtained from caries free human premolars were deminerali...
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| Published in: | Archives of oral biology 2008-11, Vol.53 (11), p.1017 |
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| Main Authors: | , , , , , , , , , |
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| container_issue | 11 |
| container_start_page | 1017 |
| container_title | Archives of oral biology |
| container_volume | 53 |
| creator | Thuy, Tran Thu Nakagaki, Haruo Kato, Kazuo Hung, Phan Ai Inukai, Junko Tsuboi, Shinji Nakagaki, Hidetaka Hirose, Mina N Igarashi, Seiji Robinson, Colin |
| description | Previous studies showed that strontium (Sr) as well as fluoride (F) can enhance enamel remineralization. The aim of this study was to evaluate the effects of Sr in combination with F on enamel remineralization in vitro. Sixty enamel specimens obtained from caries free human premolars were demineralised to produce caries-like lesions. Half of each lesion was covered with nail varnish as an untreated control. The specimens were then randomly divided into F and Sr+F treatment groups. The F group was exposed to remineralizing solutions (1.5mM CaCl(2), 0.9 mM KH(2)PO(4)) containing 1 ppm, 0.1 ppm or 0.05 ppm F. The Sr+F treatment group was exposed to the same solutions including 10 ppm Sr. After 2 weeks, lesion depth, mineral loss and percentage enamel remineralization were determined using transversal microradiography. There was a significant decrease in mineral loss in all groups (p |
| doi_str_mv | 10.1016/j.archoralbio.2008.06.005 |
| format | article |
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The aim of this study was to evaluate the effects of Sr in combination with F on enamel remineralization in vitro. Sixty enamel specimens obtained from caries free human premolars were demineralised to produce caries-like lesions. Half of each lesion was covered with nail varnish as an untreated control. The specimens were then randomly divided into F and Sr+F treatment groups. The F group was exposed to remineralizing solutions (1.5mM CaCl(2), 0.9 mM KH(2)PO(4)) containing 1 ppm, 0.1 ppm or 0.05 ppm F. The Sr+F treatment group was exposed to the same solutions including 10 ppm Sr. After 2 weeks, lesion depth, mineral loss and percentage enamel remineralization were determined using transversal microradiography. There was a significant decrease in mineral loss in all groups (p<0.001). Lesion depth was significantly reduced for all groups (p<0.05) with the exception of group F. Remineralization was significantly affected by F concentration (p=0.000). The participation of Sr resulted in a significant enhancement of remineralization (p<0.001) with a synergistic effect of the Sr+F combination (p<0.01). It was concluded that while the remineralizing process was affected by the concentration of F, there was also an interaction between F and Sr when they were used in conjunction.</description><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2008.06.005</identifier><identifier>PMID: 18672228</identifier><language>eng</language><publisher>England</publisher><subject>Bicuspid - drug effects ; Bicuspid - metabolism ; Bicuspid - pathology ; Dental Enamel - drug effects ; Dental Enamel - metabolism ; Dental Enamel - pathology ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Drug Synergism ; Fluorides, Topical - pharmacology ; Humans ; In Vitro Techniques ; Microradiography ; Minerals - metabolism ; Strontium - pharmacology ; Tooth Demineralization - metabolism ; Tooth Demineralization - pathology ; Tooth Remineralization - methods</subject><ispartof>Archives of oral biology, 2008-11, Vol.53 (11), p.1017</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18672228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thuy, Tran Thu</creatorcontrib><creatorcontrib>Nakagaki, Haruo</creatorcontrib><creatorcontrib>Kato, Kazuo</creatorcontrib><creatorcontrib>Hung, Phan Ai</creatorcontrib><creatorcontrib>Inukai, Junko</creatorcontrib><creatorcontrib>Tsuboi, Shinji</creatorcontrib><creatorcontrib>Nakagaki, Hidetaka</creatorcontrib><creatorcontrib>Hirose, Mina N</creatorcontrib><creatorcontrib>Igarashi, Seiji</creatorcontrib><creatorcontrib>Robinson, Colin</creatorcontrib><title>Effect of strontium in combination with fluoride on enamel remineralization in vitro</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Previous studies showed that strontium (Sr) as well as fluoride (F) can enhance enamel remineralization. The aim of this study was to evaluate the effects of Sr in combination with F on enamel remineralization in vitro. Sixty enamel specimens obtained from caries free human premolars were demineralised to produce caries-like lesions. Half of each lesion was covered with nail varnish as an untreated control. The specimens were then randomly divided into F and Sr+F treatment groups. The F group was exposed to remineralizing solutions (1.5mM CaCl(2), 0.9 mM KH(2)PO(4)) containing 1 ppm, 0.1 ppm or 0.05 ppm F. The Sr+F treatment group was exposed to the same solutions including 10 ppm Sr. After 2 weeks, lesion depth, mineral loss and percentage enamel remineralization were determined using transversal microradiography. There was a significant decrease in mineral loss in all groups (p<0.001). Lesion depth was significantly reduced for all groups (p<0.05) with the exception of group F. Remineralization was significantly affected by F concentration (p=0.000). The participation of Sr resulted in a significant enhancement of remineralization (p<0.001) with a synergistic effect of the Sr+F combination (p<0.01). It was concluded that while the remineralizing process was affected by the concentration of F, there was also an interaction between F and Sr when they were used in conjunction.</description><subject>Bicuspid - drug effects</subject><subject>Bicuspid - metabolism</subject><subject>Bicuspid - pathology</subject><subject>Dental Enamel - drug effects</subject><subject>Dental Enamel - metabolism</subject><subject>Dental Enamel - pathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation, Preclinical</subject><subject>Drug Synergism</subject><subject>Fluorides, Topical - pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Microradiography</subject><subject>Minerals - metabolism</subject><subject>Strontium - pharmacology</subject><subject>Tooth Demineralization - metabolism</subject><subject>Tooth Demineralization - pathology</subject><subject>Tooth Remineralization - methods</subject><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNo1T1tLwzAYDYK4Of0LEn9A65ekuT3KmBcY-NL3kbQpy2iSknaK_noD0_Ny4HAuHIQeCdQEiHg61SZ3x5TNaH2qKYCqQdQA_AqtiZK6IhzECt3O8wmKKgS5QSuihKSUqjVqd8PgugWnAc9LTnHx54B9xF0K1kez-BTxl1-OeBjPKfve4SK4aIIbcXbBR1eW_c_FWHKfvrTcoevBjLO7_-MNal927fat2n-8vm-f99XEG1VxSoFwRWnPtXXEOq61LWiYlMpCY1WvtWRc6oYJrQ2RhnXSGulE1xBgbIMeLrXT2QbXH6bsg8nfh_937Be79lQV</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Thuy, Tran Thu</creator><creator>Nakagaki, Haruo</creator><creator>Kato, Kazuo</creator><creator>Hung, Phan Ai</creator><creator>Inukai, Junko</creator><creator>Tsuboi, Shinji</creator><creator>Nakagaki, Hidetaka</creator><creator>Hirose, Mina N</creator><creator>Igarashi, Seiji</creator><creator>Robinson, Colin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200811</creationdate><title>Effect of strontium in combination with fluoride on enamel remineralization in vitro</title><author>Thuy, Tran Thu ; Nakagaki, Haruo ; Kato, Kazuo ; Hung, Phan Ai ; Inukai, Junko ; Tsuboi, Shinji ; Nakagaki, Hidetaka ; Hirose, Mina N ; Igarashi, Seiji ; Robinson, Colin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p548-522015822d59be1be599bbbb43778b04b8d997357943699a17a3c7ba7e6c41033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Bicuspid - drug effects</topic><topic>Bicuspid - metabolism</topic><topic>Bicuspid - pathology</topic><topic>Dental Enamel - drug effects</topic><topic>Dental Enamel - metabolism</topic><topic>Dental Enamel - pathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation, Preclinical</topic><topic>Drug Synergism</topic><topic>Fluorides, Topical - pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Microradiography</topic><topic>Minerals - metabolism</topic><topic>Strontium - pharmacology</topic><topic>Tooth Demineralization - metabolism</topic><topic>Tooth Demineralization - pathology</topic><topic>Tooth Remineralization - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thuy, Tran Thu</creatorcontrib><creatorcontrib>Nakagaki, Haruo</creatorcontrib><creatorcontrib>Kato, Kazuo</creatorcontrib><creatorcontrib>Hung, Phan Ai</creatorcontrib><creatorcontrib>Inukai, Junko</creatorcontrib><creatorcontrib>Tsuboi, Shinji</creatorcontrib><creatorcontrib>Nakagaki, Hidetaka</creatorcontrib><creatorcontrib>Hirose, Mina N</creatorcontrib><creatorcontrib>Igarashi, Seiji</creatorcontrib><creatorcontrib>Robinson, Colin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thuy, Tran Thu</au><au>Nakagaki, Haruo</au><au>Kato, Kazuo</au><au>Hung, Phan Ai</au><au>Inukai, Junko</au><au>Tsuboi, Shinji</au><au>Nakagaki, Hidetaka</au><au>Hirose, Mina N</au><au>Igarashi, Seiji</au><au>Robinson, Colin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of strontium in combination with fluoride on enamel remineralization in vitro</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2008-11</date><risdate>2008</risdate><volume>53</volume><issue>11</issue><spage>1017</spage><pages>1017-</pages><eissn>1879-1506</eissn><abstract>Previous studies showed that strontium (Sr) as well as fluoride (F) can enhance enamel remineralization. The aim of this study was to evaluate the effects of Sr in combination with F on enamel remineralization in vitro. Sixty enamel specimens obtained from caries free human premolars were demineralised to produce caries-like lesions. Half of each lesion was covered with nail varnish as an untreated control. The specimens were then randomly divided into F and Sr+F treatment groups. The F group was exposed to remineralizing solutions (1.5mM CaCl(2), 0.9 mM KH(2)PO(4)) containing 1 ppm, 0.1 ppm or 0.05 ppm F. The Sr+F treatment group was exposed to the same solutions including 10 ppm Sr. After 2 weeks, lesion depth, mineral loss and percentage enamel remineralization were determined using transversal microradiography. There was a significant decrease in mineral loss in all groups (p<0.001). Lesion depth was significantly reduced for all groups (p<0.05) with the exception of group F. Remineralization was significantly affected by F concentration (p=0.000). The participation of Sr resulted in a significant enhancement of remineralization (p<0.001) with a synergistic effect of the Sr+F combination (p<0.01). It was concluded that while the remineralizing process was affected by the concentration of F, there was also an interaction between F and Sr when they were used in conjunction.</abstract><cop>England</cop><pmid>18672228</pmid><doi>10.1016/j.archoralbio.2008.06.005</doi></addata></record> |
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| ispartof | Archives of oral biology, 2008-11, Vol.53 (11), p.1017 |
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| source | ScienceDirect Freedom Collection |
| subjects | Bicuspid - drug effects Bicuspid - metabolism Bicuspid - pathology Dental Enamel - drug effects Dental Enamel - metabolism Dental Enamel - pathology Dose-Response Relationship, Drug Drug Evaluation, Preclinical Drug Synergism Fluorides, Topical - pharmacology Humans In Vitro Techniques Microradiography Minerals - metabolism Strontium - pharmacology Tooth Demineralization - metabolism Tooth Demineralization - pathology Tooth Remineralization - methods |
| title | Effect of strontium in combination with fluoride on enamel remineralization in vitro |
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