Hepatic absorbed radiation dosimetry during I-131 metaiodobenzylguanidine (MIBG) therapy for refractory neuroblastoma

• Published in: European journal of nuclear medicine and molecular imaging 2008-11, Vol.35 (11), p.2105
• Main Authors: Koral, Kenneth F, Huberty, John P, Frame, Bill, Matthay, Katherine K, Maris, John M, Regan, Denise, Normolle, Daniel, Yanik, Gregory A
• Format: Article
• Language: English
• Subjects: 3-Iodobenzylguanidine - administration & dosage; 3-Iodobenzylguanidine - metabolism; 3-Iodobenzylguanidine - therapeutic use; Absorption; Adolescent; Child; Child, Preschool; Female; Humans; Liver - metabolism; Liver - radiation effects; Male; Models, Biological; Neuroblastoma - pathology; Neuroblastoma - radiotherapy; Radiation Dosage; Radiometry
• ISSN: 1619-7089
• DOI: 10.1007/s00259-008-0873-3

To compare the prediction of therapeutic hepatic radiation-absorbed dose rates from tracer imaging plus a linearity assumption to estimation based on intra-therapy imaging in (131)I metaiodobenzylguanidine (MIBG) therapy of refractory neuroblastoma. Conjugate-view images of the liver were obtained before therapy for seven patients at seven times after a tracer infusion of (131)I MIBG and at three times after the therapy infusion. Measured liver activities were converted to dose-rate estimates. Three statistical models of the rates assuming double exponential dependences on time were examined. One of the three models allowed for a multiplicative correction to the therapeutic late-phase dose-rate amplitude. Results from that model: (1) the tracer prediction of the late-phase absorbed-dose-rate amplitude was a factor of 1.75 times the intra-therapy-estimated value, and (2) the difference between tracer prediction of the radiation-absorbed dose and intra-therapy estimation of it was statistically significant, and (3) the liver radiation-absorbed dose did not reach 30 Gy. A statistical modeling analysis finds that the radiation-absorbed dose after therapy appears to be lower than that which is predicted from the linear scaling with administered activity of the tracer radiation-absorbed dose. Hepatocyte toxicity is the most likely reason but it is not high enough to produce clinically observable results.