Utility of cyclodextrins in the formulation of genistein Part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins

Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2008-11, Vol.48 (3), p.636-640
Main Authors: DARUHAZI, Agnes Emma, SZENTE, Lajos, BALOGH, Balazs, MATYUS, Péter, BENI, Szabolcs, TAKACS, Maria, GERGELY, Andras, HORVATH, Péter, SZÖKE, Eva, LEMBERKOVICS, Eva
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
beta-Cyclodextrins - chemistry
Biological and medical sciences
Chemical Phenomena
Chemistry, Pharmaceutical
Cyclodextrins - chemistry
Fundamental and applied biological sciences. Psychology
General pharmacology
Genistein - chemistry
Medical sciences
Models, Molecular
Molecular Structure
Pharmacology. Drug treatments
Solubility
Spectrophotometry, Ultraviolet
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidis spinosae radix was found to form a supramolecular, non-covalent inclusion complex with both beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), while it did not form a stable complex with alpha-CD. The guest genistein was found to spatially located in the less polar cavity of cyclodextrin. The isolated binary genistein/CD complexes appeared novel crystalline lattices. The in vitro dissolution of genistein entrapped into both beta- and gamma-CD, significantly surpassed that of the plain isoflavone.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2008.06.007