Utility of combined (18)F-fluorodeoxyglucose-positron emission tomography and computed tomography in patients with cervical metastases from unknown primary tumors

(18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) has been reported to identify primary tumors in patients with cervical metastases from cancer of unknown primary (CUP). However, few reports have assessed the use of combined FDG-PET/computed tomography (CT) in this setting. We theref...

Full description

Saved in:
Bibliographic Details
Published in:Oral oncology 2009-03, Vol.45 (3), p.218
Main Authors: Roh, Jong-Lyel, Kim, Jae Seung, Lee, Jeong Hyun, Cho, Kyung-Ja, Choi, Seung-Ho, Nam, Soon Yuhl, Kim, Sang Yoon
Format: Article
Language:English
Subjects:
Adult
Aged
Cohort Studies
Female
Fluorodeoxyglucose F18
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - secondary
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Neoplasms, Unknown Primary - diagnosis
Neoplasms, Unknown Primary - pathology
Positron-Emission Tomography - methods
Radiopharmaceuticals
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
Whole Body Imaging - methods
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) has been reported to identify primary tumors in patients with cervical metastases from cancer of unknown primary (CUP). However, few reports have assessed the use of combined FDG-PET/computed tomography (CT) in this setting. We therefore examined the utility of combined FDG-PET/CT in the detection of primary tumors and unrecognized metastases in these patients. Patients with previously untreated CUPs underwent head and neck CT and whole-body FDG-PET/CT before panendoscopy and guided biopsy. The diagnostic accuracy of CT and FDG-PET/CT in detecting primary tumors and cervical metastases was compared with that of histopathology. The ability of FDG-PET/CT to detect distant metastases was also tested. Of the 44 eligible patients, 16 had occult primary tumors in the head and neck. FDG-PET/CT was significantly more sensitive than CT for detecting primary tumors (87.5% vs. 43.7%, P=.016), but their specificity did not differ (82.1% vs. 89.3%, P=.500). Thirty-four of 44 patients underwent neck dissection; 67 of 182 dissected cervical levels had metastatic nodal diseases. On a level-by-level basis, FDG-PET/CT was significantly more sensitive than CT (94.0% vs. 71.6%, P
ISSN:1879-0593
DOI:10.1016/j.oraloncology.2008.05.010