CLINICAL EFFECT OF MICONAZOLE GEL AGAINST UPPER DIGESTIVE TRACT MYCOSIS

• Published in: Japanese journal of antibiotics 1991/02/25, Vol.44(3), pp.324-336
• Main Authors: TSUBURA, EIRO, NOMA, KEIZO, IKEMOTO, HIDEO, MORI, TAKESHI, MIKUNI, CHIKARA, OIZUMI, KOTARO, KASHIWABARA, HIDEHIKO, ITOH, AKIRA, UCHINO, HARUTO, SAWADA, HIROYOSHI, MASAOKA, TOHRU, SHIBATA, HIROTOSHI, NAGAI, KIYOYASU, SHINOHARA, YOSHIKI, NAKAYAMA, SHIRO, NAGAI, KENICHI, NAKAYAMA, TADASHI, KOZURU, MITSUO, YAMAGUCHI, HIDEYO, UCHIDA, KATSUHISA
• Format: Article
• Language: Japanese
• Subjects: Adolescent; Adult; Aged; Candidiasis - drug therapy; Candidiasis, Oral - drug therapy; Esophageal Diseases - drug therapy; Female; Humans; Male; Miconazole - adverse effects; Miconazole - therapeutic use; Middle Aged
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.44.324

A total of 43 patients, c omprising 41 patients with oral candidiasisa nd 2 with esophageal candidiasis, w ere treated with miconazole (MCZ) gel to assess its efHcacy and safety intreating upper digestivet ractm ycosis. The efHcacy of the drug was evaluablei n 33 of them, consistingo f32 patientsw ith oral candidiasisa nd 1 with esophageal candidiasis.T he clinicale Mcacy rate of the drug against oral candidiasisw as 87.5% (28/32 patients), a nd the clinicalr esponse was good in the 1 evaluable patient with esophageal candidiasis The safety of the drug was assessed in 40 patients. In 3 (7.5%) of them, nausea occurred as an adverse event, but was not particularly serious in any of them. No abnormal laboratory test values caused by the drug were observed. The results suggested that MCZ gel would be a very useful drug in treating oral and esophageal candidiasis.